Adult neural stem cells in distinct microdomains generate previously unknown interneuron types
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Author
Fuentealba, Luis C.
Sanders, Timothy A.
Magno, Lorenza
Kessaris, Nicoletta
Alvarez-Buylla, Arturo
Published Version
https://doi.org/10.1038/nn.3610Metadata
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Merkle, Florian T., Luis C. Fuentealba, Timothy A. Sanders, Lorenza Magno, Nicoletta Kessaris, and Arturo Alvarez-Buylla. 2014. “Adult neural stem cells in distinct microdomains generate previously unknown interneuron types.” Nature neuroscience 17 (2): 207-214. doi:10.1038/nn.3610. http://dx.doi.org/10.1038/nn.3610.Abstract
Throughout life, neural stem cells (NSCs) in different domains of the ventricular-subventricular zone (V-SVZ) of the adult rodent brain generate several subtypes of interneurons that regulate the function of the olfactory bulb (OB). The full extent of diversity among adult NSCs and their progeny is not known. Here, we report the generation of at least four previously unknown OB interneuron subtypes that are produced in finely patterned progenitor domains in the anterior ventral V-SVZ of both the neonatal and adult brain. Progenitors of these novel interneurons are responsive to sonic hedgehog (SHH) and are organized into microdomains that correlate with the expression domains of the Nkx6.2 and Zic family of transcription factors. This work reveals an unexpected degree of complexity in the specification and patterning of NSCs in the postnatal mouse brain.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100623/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12785854
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