Unraveling the clonal hierarchy of somatic genomic aberrations
View/ Open
Author
Prandi, Davide
Romanel, Alessandro
Barbieri, Christopher E
Mosquera, Juan-Miguel
Fontugne, Jacqueline
Beltran, Himisha
Sboner, Andrea
Rubin, Mark A
Demichelis, Francesca
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1186/s13059-014-0439-6Metadata
Show full item recordCitation
Prandi, D., S. C. Baca, A. Romanel, C. E. Barbieri, J. Mosquera, J. Fontugne, H. Beltran, et al. 2014. “Unraveling the clonal hierarchy of somatic genomic aberrations.” Genome Biology 15 (8): 439. doi:10.1186/s13059-014-0439-6. http://dx.doi.org/10.1186/s13059-014-0439-6.Abstract
Defining the chronology of molecular alterations may identify milestones in carcinogenesis. To unravel the temporal evolution of aberrations from clinical tumors, we developed CLONET, which upon estimation of tumor admixture and ploidy infers the clonal hierarchy of genomic aberrations. Comparative analysis across 100 sequenced genomes from prostate, melanoma, and lung cancers established diverse evolutionary hierarchies, demonstrating the early disruption of tumor-specific pathways. The analyses highlight the diversity of clonal evolution within and across tumor types that might be informative for risk stratification and patient selection for targeted therapies. CLONET addresses heterogeneous clinical samples seen in the setting of precision medicine. Electronic supplementary material The online version of this article (doi:10.1186/s13059-014-0439-6) contains supplementary material, which is available to authorized users.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167267/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:13347406
Collections
- FAS Scholarly Articles [18292]
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)