Synthesis and patterning of tunable multiscale materials with engineered cells
View/ Open
Author
Chen, Allen Y.
Deng, Zhengtao
Billings, Amanda N.
Seker, Urartu O.S.
Lu, Michelle Y.
Citorik, Robert J.
Zakeri, Bijan
Lu, Timothy K.
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/nmat3912Metadata
Show full item recordCitation
Chen, Allen Y., Zhengtao Deng, Amanda N. Billings, Urartu O.S. Seker, Michelle Y. Lu, Robert J. Citorik, Bijan Zakeri, and Timothy K. Lu. 2014. “Synthesis and patterning of tunable multiscale materials with engineered cells.” Nature materials 13 (5): 515-523. doi:10.1038/nmat3912. http://dx.doi.org/10.1038/nmat3912.Abstract
Many natural biological systems - such as biofilms, shells and skeletal tissues - are able to assemble multifunctional and environmentally responsive multiscale assemblies of living and non-living components. Here, by using inducible genetic circuits and cellular communication circuits to regulate Escherichia coli curli amyloid production, we show that E. coli cells can organize self-assembling amyloid fibrils across multiple length scales, producing amyloid-based materials that are either externally controllable or undergo autonomous patterning. We also interfaced curli fibrils with inorganic materials, such as gold nanoparticles (AuNPs) and quantum dots (QDs), and used these capabilities to create an environmentally responsive biofilm-based electrical switch, produce gold nanowires and nanorods, co-localize AuNPs with CdTe/CdS QDs to modulate QD fluorescence lifetimes, and nucleate the formation of fluorescent ZnS QDs. This work lays a foundation for synthesizing, patterning, and controlling functional composite materials with engineered cells.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063449/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:13454699
Collections
- FAS Scholarly Articles [18292]
Contact administrator regarding this item (to report mistakes or request changes)