Circulating miR-765 and miR-149: Potential Noninvasive Diagnostic Biomarkers for Geriatric Coronary Artery Disease Patients
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Author
Ali Sheikh, Md Sayed
Xia, Ke
Li, Fei
Deng, Xu
Salma, Umme
Deng, Hai
Wei Wei, Liu
Yang, Tian-Lun
Peng, Jun
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1155/2015/740301Metadata
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Ali Sheikh, Md Sayed, Ke Xia, Fei Li, Xu Deng, Umme Salma, Hai Deng, Liu Wei Wei, Tian-Lun Yang, and Jun Peng. 2015. “Circulating miR-765 and miR-149: Potential Noninvasive Diagnostic Biomarkers for Geriatric Coronary Artery Disease Patients.” BioMed Research International 2015 (1): 740301. doi:10.1155/2015/740301. http://dx.doi.org/10.1155/2015/740301.Abstract
The purpose of this study was to evaluate the diagnostic value of circulating miR-765 and miR-149 as noninvasive early biomarkers for geriatric coronary artery disease (CAD) patients. A total of 69 angiographically documented CAD patients including 37 stable CAD (72.9 ± 4.2 years) and 32 unstable CAD (72.03 ± 4.3 years) and 20 healthy subjects (71.7 ± 5.2 years), matched for age, sex, smoking habit, hypertension, and diabetes, were enrolled in this study. Compared with healthy subjects, circulating miR-765 levels were increased by 2.9-fold in stable CAD and 5.8-fold in unstable CAD patients, respectively, while circulating miR-149 levels were downregulated by 3.5-fold in stable CAD and 4.2-fold in unstable CAD patients, respectively. Furthermore, plasma levels of miR-765 were found to be positively correlated with ages within control, stable, and unstable groups. The ROC curves of miR-765 and miR-149 represented significant diagnostic values with an area under curve (AUC) of 0.959, 0.972 and 0.938, 0.977 in stable CAD patients and unstable CAD patients as compared with healthy subjects, respectively. Plasma levels of miR-765 and miR-149 might be used as noninvasive biomarkers for the diagnosis of CAD in geriatric people.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312568/pdf/Terms of Use
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