A Comparative Encyclopedia of DNA Elements in the Mouse Genome
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Author
Yue, Feng
Cheng, Yong
Breschi, Alessandra
Vierstra, Jeff
Wu, Weisheng
Ryba, Tyrone
Sandstrom, Richard
Ma, Zhihai
Davis, Carrie
Pope, Benjamin D.
Shen, Yin
Pervouchine, Dmitri D.
Djebali, Sarah
Thurman, Bob
Kaul, Rajinder
Rynes, Eric
Kirilusha, Anthony
Marinov, Georgi K.
Williams, Brian A.
Trout, Diane
Amrhein, Henry
Fisher-Aylor, Katherine
Antoshechkin, Igor
DeSalvo, Gilberto
See, Lei-Hoon
Fastuca, Meagan
Drenkow, Jorg
Zaleski, Chris
Dobin, Alex
Prieto, Pablo
Lagarde, Julien
Bussotti, Giovanni
Tanzer, Andrea
Denas, Olgert
Li, Kanwei
Bender, M. A.
Zhang, Miaohua
Byron, Rachel
Groudine, Mark T.
McCleary, David
Pham, Long
Ye, Zhen
Kuan, Samantha
Edsall, Lee
Wu, Yi-Chieh
Rasmussen, Matthew D.
Bansal, Mukul S.
Keller, Cheryl A.
Morrissey, Christapher S.
Mishra, Tejaswini
Jain, Deepti
Dogan, Nergiz
Harris, Robert S.
Cayting, Philip
Kawli, Trupti
Boyle, Alan P.
Euskirchen, Ghia
Kundaje, Anshul
Lin, Shin
Lin, Yiing
Jansen, Camden
Malladi, Venkat S.
Cline, Melissa S.
Erickson, Drew T.
Kirkup, Vanessa M
Learned, Katrina
Sloan, Cricket A.
Rosenbloom, Kate R.
de Sousa, Beatriz Lacerda
Beal, Kathryn
Pignatelli, Miguel
Flicek, Paul
Lian, Jin
Kahveci, Tamer
Lee, Dongwon
Kent, W. James
Santos, Miguel Ramalho
Herrero, Javier
Notredame, Cedric
Johnson, Audra
Vong, Shinny
Lee, Kristen
Bates, Daniel
Neri, Fidencio
Diegel, Morgan
Canfield, Theresa
Sabo, Peter J.
Wilken, Matthew S.
Reh, Thomas A.
Giste, Erika
Shafer, Anthony
Kutyavin, Tanya
Haugen, Eric
Dunn, Douglas
Reynolds, Alex P.
Neph, Shane
Humbert, Richard
Hansen, R. Scott
De Bruijn, Marella
Selleri, Licia
Rudensky, Alexander
Josefowicz, Steven
Samstein, Robert
Eichler, Evan E.
Levasseur, Dana
Papayannopoulou, Thalia
Chang, Kai-Hsin
Skoultchi, Arthur
Gosh, Srikanta
Disteche, Christine
Treuting, Piper
Wang, Yanli
Weiss, Mitchell J.
Blobel, Gerd A.
Good, Peter J.
Lowdon, Rebecca F.
Adams, Leslie B.
Zhou, Xiao-Qiao
Pazin, Michael J.
Feingold, Elise A.
Wold, Barbara
Taylor, James
Kellis, Manolis
Mortazavi, Ali
Weissman, Sherman M.
Stamatoyannopoulos, John
Snyder, Michael P.
Guigo, Roderic
Gingeras, Thomas R.
Gilbert, David M.
Hardison, Ross C.
Beer, Michael A.
Ren, Bing
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https://doi.org/10.1038/nature13992Metadata
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Yue, F., Y. Cheng, A. Breschi, J. Vierstra, W. Wu, T. Ryba, R. Sandstrom, et al. 2014. “A Comparative Encyclopedia of DNA Elements in the Mouse Genome.” Nature 515 (7527): 355-364. doi:10.1038/nature13992. http://dx.doi.org/10.1038/nature13992.Abstract
Summary As the premier model organism in biomedical research, the laboratory mouse shares the majority of protein-coding genes with humans, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications, and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of other sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266106/pdf/Terms of Use
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