Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility
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Author
Yin, Xianyong
Low, Hui Qi
Wang, Ling
Li, Yonghong
Ellinghaus, Eva
Han, Jiali
Estivill, Xavier
Sun, Liangdan
Zuo, Xianbo
Shen, Changbing
Zhu, Caihong
Zhang, Anping
Sanchez, Fabio
Padyukov, Leonid
Catanese, Joseph J.
Krueger, Gerald G.
Duffin, Kristina Callis
Mucha, Sören
Weichenthal, Michael
Weidinger, Stephan
Lieb, Wolfgang
Foo, Jia Nee
Li, Yi
Sim, Karseng
Liany, Herty
Irwan, Ishak
Teo, Yikying
Theng, Colin T. S.
Gupta, Rashmi
Bowcock, Anne
Qureshi, Abrar A.
de Bakker, Paul I. W.
Seielstad, Mark
Liao, Wilson
Ståhle, Mona
Franke, Andre
Zhang, Xuejun
Liu, Jianjun
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ncomms7916Metadata
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Yin, X., H. Q. Low, L. Wang, Y. Li, E. Ellinghaus, J. Han, X. Estivill, et al. 2015. “Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.” Nature Communications 6 (1): 6916. doi:10.1038/ncomms7916. http://dx.doi.org/10.1038/ncomms7916.Abstract
Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic genome-wide meta-analysis (GWMA) of psoriasis in 15,369 cases and 19,517 controls of Caucasian and Chinese ancestries. We identify four novel associations at LOC144817, COG6, RUNX1 and TP63, as well as three novel secondary associations within IFIH1 and IL12B. Fine-mapping analysis of MHC region demonstrates an important role for all three HLA class I genes and a complex and heterogeneous pattern of HLA associations between Caucasian and Chinese populations. Further, trans-ethnic comparison suggests population-specific effect or allelic heterogeneity for 11 loci. These population-specific effects contribute significantly to the ethnic diversity of psoriasis prevalence. This study not only provides novel biological insights into the involvement of immune and keratinocyte development mechanism, but also demonstrates a complex and heterogeneous genetic architecture of psoriasis susceptibility across ethnic populations.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423213/pdf/Terms of Use
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