Individually based measurement of temporal summation evoked by a noxious tonic heat paradigm
Citation
Suzan, Erica, Joshua Aviram, Roi Treister, Elon Eisenberg, and Dorit Pud. 2015. “Individually based measurement of temporal summation evoked by a noxious tonic heat paradigm.” Journal of Pain Research 8 (1): 409-415. doi:10.2147/JPR.S83352. http://dx.doi.org/10.2147/JPR.S83352.Abstract
Background: A model for measuring temporal summation (TS) by tonic noxious stimulation was recently proposed. However, methodological variations between studies make it difficult to reach a consensus regarding the way TS should be applied and calculated. The present study aimed to present a calculation method of TS magnitude produced by a tonic heat model in a large cohort of healthy subjects. Methods: Noxious heat stimulation (46.5°C/2 minutes) was applied to the forearm of 154 subjects who continuously rated pain intensity using a computerized visual analog scale. TS was calculated by “mean group” and “individual” approaches. Results: A “typical” pattern of pain response, characterized by a peak pain followed by a decrease in intensity to a nadir and subsequently a progressive increase in pain scores, was exhibited by 86.4% of the subjects. Using the “mean group” and “individual” calculation approaches, the mean ± standard deviation magnitudes of TS were 31.4±27.5 and 41.0±26.0, respectively (P<0.001). Additionally, using the individualized approach, we identified a different (“atypical”) response pattern among the rest of the subjects (13.6%). Conclusion: The results support the tonic heat model of TS for future utilization. The individualized TS calculation method seems advantageous since it better reflects individual magnitudes of TS.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509538/pdf/Terms of Use
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