Browsing FAS Scholarly Articles by Title
Now showing items 3223-3242 of 18292
-
Crystal Growth Kinetics of Boron Oxide Under Pressure
(American Institute of Physics, 1985)We have measured the crystal growth rate u of B2O3-I in the amorphous phase, as it varied over five orders of magnitude with changes in temperature and pressure. We eliminated the crystal nucleation barrier by seeding the ... -
Crystal melting and black holes
(Springer Verlag, 2007)It has recently been shown that the statistical mechanics of crystal melting maps to A-model topological string amplitudes on non-compact Calabi-Yau spaces. In this note we establish a one to one correspondence between two ... -
Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter
(Elsevier BV, 2016)The widely-conserved natural resistance associated macrophage protein (Nramp) family of divalent metal transporters enables manganese import in bacteria and dietary iron uptake in mammals. We determined the crystal structure ... -
Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis
(National Academy of Sciences, 2007)Peptidoglycan is an essential polymer that forms a protective shell around bacterial cell membranes. Peptidoglycan biosynthesis is the target of many clinically used antibiotics, including the beta-lactams, imipenems, ... -
Crystal Structure of Neocarzinostatin, an Antitumor Protein-Chromophore Complex
(American Association for the Advancement of Science, 1993)Structures of the protein-chromophore complex and the apoprotein form of neocarzinostatin were determined at 1.8 angstrom resolution. Neocarzinostatin is composed of a labile chromophore with DNA-cleaving activity and a ... -
Crystal Structure of the FERM-SH2 Module of Human Jak2
(Public Library of Science, 2016)Jak-family tyrosine kinases mediate signaling from diverse cytokine receptors. Binding of Jaks to their cognate receptors is mediated by their N-terminal region, which contains FERM and SH2 domains. Here we describe the ... -
Crystal Structure of the Yeast Inner Kinetochore Subunit cep3p
(Elsevier, 2007)In budding yeast, the four-protein CBF3 complex (Skp1p-Ctf13p-Cep3p-Ndc10p) initiates kinetochore assembly by binding to the CDEIII locus of centromeric DNA. A Cep3p dimer recruits a Ctf13p-Skp1p heterodimer and contacts ... -
Crystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease H
(Portland Press Ltd., 2012)RNase H (retroviral ribonuclease H) cleaves the phosphate backbone of the RNA template within an RNA/DNA hybrid to complete the synthesis of double-stranded viral DNA. In the present study we have determined the complete ... -
Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation
(Public Library of Science, 2008)Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase required for cell migration, proliferation and survival. FAK overexpression has been documented in diverse human cancers and is associated with a poor clinical ... -
The Crystal Structures of Yeast Get3 Suggest a Mechanism for Tail-Anchored Protein Membrane Insertion
(Public Library of Science, 2009)Tail-anchored (TA) proteins represent a unique class of membrane proteins that contain a single C-terminal transmembrane helix. The post-translational insertion of the yeast TA proteins into the ER membrane requires the ... -
Crystalline monolayer surface of liquid Au–Cu–Si–Ag–Pd: Metallic glass former
(AIP Publishing, 2011)It is demonstrated by means of x-ray synchrotron reflectivity and diffraction that the surface of the liquid phase of the bulk metallic glass forming alloy Au_49 Cu_26.9 Si_16.3 Ag_5.5 Pd_2.3 consists of a two-dimensional ... -
Crystalline Phases of Alkyl-Thiol Monolayers on Liquid Mercury
(American Physical Society, 2005)The structure of octadecanethiol monolyers on liquid Hg surfaces, measured with subangstrom resolution, evolves with increasing coverage from a laterally disordered phase of surface-parallel molecules to ordered rotator ... -
Crystalline Surface Phases of the Liquid Au-Si Eutectic Alloy
(American Physical Society, 2007)A two-dimensional crystalline layer is found at the surface of the liquid eutectic Au82Si18 alloy above its melting point TM=359 °C. Underlying this crystalline layer, we find a layered structure, 6–7 atomic layers thick. ... -
Crystallinities and Light Emitting Properties of Nanostructured SiGe Alloy Prepared by Pulsed Laser Ablation in Inert Background Gases
(1999)For studying the material properties of nanostructured group IV materials, we have developed a pulsed laser ablation method into inert background gases. SiGe alloy nanocrystallites have the possibility of novel band structure ... -
Crystallization and reentrant melting of charged colloids in nonpolar solvents
(American Physical Society, 2015)We explore the crystallization of charged colloidal particles in a nonpolar solvent mixture. We simultaneously charge the particles and add counterions to the solution with aerosol-OT (AOT) reverse micelles. At low AOT ... -
CS50 Sandbox: Secure Execution of Untrusted Code
(Association for Computing Machinery, 2013)We introduce CS50 Sandbox, an environment for secure execution of untrusted code. Implemented as an asynchronous HTTP server, CS50 Sandbox offers clients the ability to execute programs (both interactive and non-interactive) ... -
Csm4, in Collaboration with Ndj1, Mediates Telomere-Led Chromosome Dynamics and Recombination during Yeast Meiosis
(Public Library of Science, 2008)Chromosome movements are a general feature of mid-prophase of meiosis. In budding yeast, meiotic chromosomes exhibit dynamic movements, led by nuclear envelope (NE)-associated telomeres, throughout the zygotene and pachytene ... -
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia
(The Rockefeller University Press, 2014)Despite extensive insights into the underlying genetics and biology of acute myeloid leukemia (AML), overall survival remains poor and new therapies are needed. We found that casein kinase 1 α (Csnk1a1), a serine-threonine ... -
Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex
(Elsevier BV, 2016)While several transcriptional controls over the size and relative position of cortical areas have been identified, less is known about regulators that direct acquisition of area-specific characteristics. Here, we report ... -
Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers
(Elsevier BV, 2016)The molecular linkage between neocortical projection neuron subtype and area development, which enables the establishment of functional areas by projection neuron populations appropriate for specific sensory and motor ...