Browsing FAS Scholarly Articles by Title
Now showing items 3934-3953 of 18292
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Discovery of Novel Rhabdoviruses in the Blood of Healthy Individuals from West Africa
(Public Library of Science, 2015)Next-generation sequencing (NGS) has the potential to transform the discovery of viruses causing unexplained acute febrile illness (UAFI) because it does not depend on culturing the pathogen or a priori knowledge of the ... -
Discovery of Radio Afterglow from the Most Distant Cosmic Explosion
(IOP Publishing, 2010)We report the discovery of radio afterglow emission from the gamma-ray burst GRB 090423, which exploded at a redshift of 8.3, making it the object with the highest known redshift in the Universe. By combining our radio ... -
Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma
(National Academy of Sciences, 2016)Multiple myeloma (MM) has proven clinically susceptible to modulation of pathways of protein homeostasis. Blockade of proteasomal degradation of polyubiquitinated misfolded proteins by the proteasome inhibitor bortezomib ... -
The Discovery of Slowness in Music
(Fordham University Press, 2015) -
Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death
(American Chemical Society, 2013)Elevation of reactive oxygen species (ROS) levels has been observed in many cancer cells relative to nontransformed cells, and recent reports have suggested that small-molecule enhancers of ROS may selectively kill cancer ... -
Discovery of Small-Molecule Modulators of the Sonic Hedgehog Pathway
(American Chemical Society, 2013)The Hedgehog signaling pathway is involved in the development of multicellular organisms and, when deregulated, can contribute to certain cancers, among other diseases. The molecular characterization of the pathway, which ... -
Discovery of the Very Red Near-Infrared and Optical Afterglow of the Short-Duration Grb 070724a
(IOP Publishing, 2009)We report the discovery of the near-infrared and optical afterglow of the short-duration gamma-ray burst GRB 070724A. The afterglow is detected in iJHKs observations starting 2.3 hr after the burst with Ks = 19.59± 0.16 ... -
Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)
(American Chemical Society, 2014)We developed a pharmacophore model for type II inhibitors that was used to guide the construction of a library of kinase inhibitors. Kinome-wide selectivity profiling of the library resulted in the identification of a ... -
Discovery of Water Maser Emission in Eight AGNs with 70 m Antennas of NASA’s Deep Space Network
(IOP Publishing, 2006)We report the discovery of water maser emission in eight active galactic nuclei (AGN) with the 70-m NASA Deep Space Network (DSN) antennas at Tidbinbilla, Australia and Robledo, Spain. The positions of the newly discovered ... -
Discovery of Water Maser Emission in Five AGNs and a Possible Correlation Between Water Maser and Nuclear 2–10 keV Luminosities
(IOP Publishing, 2006)We report the discovery of water maser emission in five active galactic nuclei (AGN) with the 100-m Green Bank Telescope (GBT). The positions of the newly discovered masers, measured with the VLA, are consistent with the ... -
Discovery of widespread GTP-binding motifs in genomic DNA and RNA
(Elsevier BV, 2013)Biological RNAs that bind small-molecules have been implicated in a variety of regulatory and catalytic processes. Inspired by these examples, we used in vitro selection to search a pool of genomeencoded RNA fragments for ... -
Discrete genetic modules are responsible for complex burrow evolution in Peromyscus mice
(Nature Publishing Group, 2013)Relative to morphological traits, we know little about how genetics influence the evolution of complex behavioural differences in nature1. It is unclear how the environment influences natural variation in heritable behaviour, ... -
Discrete One-forms on Meshes and Applications to 3D mesh Parameterization
(Elsevier, 2006)We describe how some simple properties of discrete one-forms directly relate to some old and new results concerning the parameterization of 3D mesh data. Our first result is an easy proof of Tutte's celebrated “spring-embedding” ... -
Discrete Single-Photon Quantum Walks with Tunable Decoherence
(American Physical Society, 2010)Quantum walks have a host of applications, ranging from quantum computing to the simulation of biological systems. We present an intrinsically stable, deterministic implementation of discrete quantum walks with single ... -
Discrete/Continuous: Music and Media Theory after Kittler
(University of California Press, 2017-04-01)At first blush, the pair discrete/continuous seems to take us far from the concerns of musicology and place us firmly in the realm of statistics, data analysis, and number crunching. Put graphically, “discrete data” ... -
Discretizing gravity in warped spacetime
(Springer Verlag, 2005)We investigate the discretized version of the compact Randall-Sundrum model. By studying the mass eigenstates of the lattice theory, we demonstrate that for warped space, unlike for flat space, the strong coupling scale ... -
Discriminate Biopower and Everyday Biopolitics: Views on Sickle Cell Testing in Dakar
(Taylor & Francis, 2004)Many physicians in Senegal and France, where most Senegalese sickle cell specialists are partially trained, assume that genetic testing that could imply selective abortion for people with sickle cell would run counter to ... -
Discriminating between the physical processes that drive spheroid size evolution
(Oxford University Press, 2010)Observations have shown that massive galaxies at high redshift have much smaller effective radii than galaxies of similar mass today; however, recent work has shown that they have similar central densities. The primary ... -
Discriminating tissue stiffness with a haptic catheter: Feeling the inside of the beating heart
(Institute of Electrical and Electronics Engineers, 2011)Catheter devices allow physicians to access the inside of the human body easily and painlessly through natural orifices and vessels. Although catheters allow for the delivery of fluids and drugs, the deployment of devices, ... -
Discriminating topology in galaxy distributions using network analysis
(Oxford University Press, 2016)The large-scale distribution of galaxies is generally analysed using the two-point correlation function. However, this statistic does not capture the topology of the distribution, and it is necessary to resort to higher ...