Now showing items 4099-4118 of 18256

    • Divination and Power: A Multi-regional View of the Development of Oracle Bone Divination in Early China 

      Flad, Rowan (University of Chicago Press, 2008)
      Divination is a form of ritual practice frequently employed as an important source of social and political power. Elaborate forms of divination can be crucial to state control, and the power of elaborated divining techniques ...
    • DNA barcode reference library for Iberian butterflies enables a continental-scale preview of potential cryptic diversity 

      Dincă, Vlad; Montagud, Sergio; Talavera, Gerard; Hernández-Roldán, Juan; Munguira, Miguel L.; García-Barros, Enrique; Hebert, Paul D. N.; Vila, Roger (Nature Publishing Group, 2015)
      How common are cryptic species - those overlooked because of their morphological similarity? Despite its wide-ranging implications for biology and conservation, the answer remains open to debate. Butterflies constitute the ...
    • DNA Damage in Preserved Specimens and Tissue Samples: A Molecular Assessment 

      Zimmermann, Juergen; Hajibabaei, Mehrdad; Blackburn, David C; Hanken, James; Cantin, Elizabeth; Posfai, Janos; Evans, Thomas C., Jr. (BioMed Central, 2008)
      The extraction of genetic information from preserved tissue samples or museum specimens is a fundamental component of many fields of research, including the Barcode of Life initiative, forensic investigations, biological ...
    • DNA Enabled Self-Assembly of Plasmonic Nanoclusters 

      Fan, Jonathan A.; He, Yu; Bao, Kui; Wu, Chihhui; Bao, Jiming; Schade, Nicholas B.; Manoharan, Vinothan N.; Shvets, Gennady; Nordlander, Peter; Liu, David R.; Capasso, Federico (American Chemical Society, 2011)
      DNA nanotechnology provides a versatile foundation for the chemical assembly of nanostructures. Plasmonic nanoparticle assemblies are of particular interest because they can be tailored to exhibit a broad range of ...
    • DNA extraction protocols cause differences in 16S rRNA amplicon sequencing efficiency but not in community profile composition or structure 

      Rubin, Benjamin E R; Sanders, Jon G; Hampton-Marcell, Jarrad; Owens, Sarah M; Gilbert, Jack A; Moreau, Corrie S (BlackWell Publishing Ltd, 2014)
      The recent development of methods applying next-generation sequencing to microbial community characterization has led to the proliferation of these studies in a wide variety of sample types. Yet, variation in the physical ...
    • DNA interstrand cross-link repair requires replication fork convergence 

      Zhang, Jieqiong; Dewar, James M.; Budzowska, Magda; Motnenko, Anna; Cohn, Martin A.; Walter, Johannes C. (2014)
      DNA interstrand cross-links (ICLs) prevent strand separation during DNA replication and transcription and are therefore extremely cytotoxic. In metazoans, a major pathway of ICL repair is coupled to DNA replication and ...
    • DNA Lesion Recognition by the Bacterial Repair Enzyme MutM 

      Fromme, J. Christopher; Verdine, Gregory L. (American Society for Biochemistry and Molecular Biology, 2003)
      MutM is a bacterial DNA glycosylase that removes the mutagenic lesion 8-oxoguanine (oxoG) from duplex DNA. The means of oxoG recognition by MutM (also known as Fpg) is of fundamental interest, in light of the vast excess ...
    • DNA Ligase-Mediated Translation of DNA Into Densely Functionalized Nucleic Acid Polymers 

      Hili, Ryan; Niu, Jia; Liu, David Ruchien (American Chemical Society, 2012)
      We developed a method to translate DNA sequences into densely functionalized nucleic acids by using T4 DNA ligase to mediate the DNA-templated polymerization of 5′-phosphorylated trinucleotides containing a wide variety ...
    • DNA methylation dynamics of the human preimplantation embryo 

      Smith, Zachary D.; Chan, Michelle M.; Humm, Kathryn C.; Karnik, Rahul; Mekhoubad, Shila; Regev, Aviv; Eggan, Kevin; Meissner, Alexander (2014)
      In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and stably distributed across the genome, with local, cell type-specific regulation directed by DNA binding factors1-3. This comparatively ...
    • DNA methylation Landscape of body size variation in sheep 

      Cao, Jiaxue; Wei, Caihong; Liu, Dongming; Wang, Huihua; Wu, Mingming; Xie, Zhiyuan; Capellini, Terence D.; Zhang, Li; Zhao, Fuping; Li, Li; Zhong, Tao; Wang, Linjie; Lu, Jian; Liu, Ruizao; Zhang, Shifang; Du, Yongfei; Zhang, Hongping; Du, Lixin (Nature Publishing Group, 2015)
      Sub-populations of Chinese Mongolian sheep exhibit significant variance in body mass. In the present study, we sequenced the whole genome DNA methylation in these breeds to detect whether DNA methylation plays a role in ...
    • DNA methylation Landscape of body size variation in sheep 

      Cao, Jiaxue; Wei, Caihong; Liu, Dongming; Wang, Huihua; Wu, Mingming; Xie, Zhiyuan; Capellini, Terence D.; Zhang, Li; Zhao, Fuping; Li, Li; Zhong, Tao; Wang, Linjie; Lu, Jian; Liu, Ruizao; Zhang, Shifang; Du, Yongfei; Zhang, Hongping; Du, Lixin (Nature Publishing Group, 2015)
      Sub-populations of Chinese Mongolian sheep exhibit significant variance in body mass. In the present study, we sequenced the whole genome DNA methylation in these breeds to detect whether DNA methylation plays a role in ...
    • DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease 

      Sanchez-Mut, Jose V.; Aso, Ester; Panayotis, Nicolas; Lott, Ira; Dierssen, Mara; Rabano, Alberto; Urdinguio, Rocio G.; Fernandez, Agustin F.; Astudillo, Aurora; Martin-Subero, Jose I.; Balint, Balazs; Fraga, Mario F.; Gomez, Antonio; Gurnot, Cecile; Roux, Jean-Christophe; Avila, Jesus; Hensch, Takao K.; Ferrer, Isidre; Esteller, Manel (Oxford University Press, 2013)
      The central nervous system has a pattern of gene expression that is closely regulated with respect to functional and anatomical regions. DNA methylation is a major regulator of transcriptional activity, and aberrations in ...
    • DNA methylation signatures link prenatal famine exposure to growth and metabolism 

      Tobi, Elmar W.; Goeman, Jelle J.; Monajemi, Ramin; Gu, Hongcang; Putter, Hein; Zhang, Yanju; Slieker, Roderick C.; Stok, Arthur P.; Thijssen, Peter E.; Müller, Fabian; van Zwet, Erik W.; Bock, Christoph; Meissner, Alexander; Lumey, L. H.; Eline Slagboom, P.; Heijmans, Bastiaan T. (Nature Pub. Group, 2014)
      Periconceptional diet may persistently influence DNA methylation levels with phenotypic consequences. However, a comprehensive assessment of the characteristics of prenatal malnutrition-associated differentially methylated ...
    • DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish 

      Liu, Xiaohui; Jia, Xiaoe; Yuan, Hao; Ma, Ke; Chen, Yi; Jin, Yi; Deng, Min; Pan, Weijun; Chen, Saijuan; Chen, Zhu; de The, Hugues; Zon, Leonard I; Zhou, Yi; Zhou, Jun; Zhu, Jun (BioMed Central, 2015)
      Background: DNA methyltransferase 1 (Dnmt1) regulates expression of many critical genes through maintaining parental DNA methylation patterns on daughter DNA strands during mitosis. It is essential for embryonic development ...
    • DNA molecules and configurations in a solid-state nanopore microscope 

      Li, Jiali; Gershow, Marc; Stein, Derek; Brandin, Eric Richard; Golovchenko, Jene Andrew (Nature Publishing Group, 2003)
      A nanometre scale pore in a solid state membrane provides a new way to electronically probe the structure of single linear polymers, including those of biological interest in their native environments. Previous work with ...
    • DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader 

      Rock, Jeremy M.; Lang, Ulla F.; Chase, Michael R.; Ford, Christopher B.; Gerrick, Elias R.; Gawande, Richa; Coscolla, Mireia; Gagneux, Sebastien; Fortune, Sarah M.; Lamers, Meindert H. (2015)
      The DNA replication machinery is an important target for antibiotic development for increasingly drug resistant bacteria including Mycobacterium tuberculosis1. While blocking DNA replication leads to cell death, disrupting ...
    • DNA replication timing and higher-order nuclear organization determine single nucleotide substitution patterns in cancer genomes 

      Liu, Lin; De, Subhajyoti; Michor, Franziska (2013)
      Single nucleotide substitutions (SNS) are a defining characteristic of cancer genomes. Many SNS in cancer genomes arise due to errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA ...
    • DNA Unzipping Phase Diagram Calculated Via Replica Theory 

      Roland, C. Brian; Hatch, Kristi Adamson; Prentiss, Mara; Shakhnovich, Eugene Isaacovitch (American Physical Society, 2009)
      We show how single-molecule unzipping experiments can provide strong evidence that the zero-force melting transition of long molecules of natural dsDNA should be classified as a phase transition of the higher-order type ...
    • A DNA-based molecular probe for optically reporting cellular traction forces 

      Blakely, Brandon L.; Dumelin, Christoph E.; Trappmann, Britta; McGregor, Lynn M.; Choi, Colin K.; Anthony, Peter C.; Duesterberg, Van K.; Baker, Brendon M.; Block, Steven M.; Liu, David R.; Chen, Christopher S. (2014)
      We developed molecular tension probes (TPs) that report traction forces of adherent cells with high spatial resolution, can be linked to virtually any surface, and obviate monitoring deformations of elastic substrates. TPs ...
    • DNA-Binding Specificity Changes in the Evolution of Forkhead Transcription Factors 

      Nakagawa, So; Gisselbrecht, Stephen; Rogers, Julia Maria; Hartl, Daniel L.; Bulyk, Martha Leonia (Proceedings of the National Academy of Sciences, 2013)
      The evolution of transcriptional regulatory networks entails the expansion and diversification of transcription factor (TF) families. The forkhead family of TFs, defined by a highly conserved winged helix DNA-binding domain ...