Browsing FAS Scholarly Articles by Keyword "Cell Biology"

Now showing items 1-20 of 62

    • 4-Phenylbutyrate Attenuates the ER Stress Response and Cyclic AMP Accumulation in DYT1 Dystonia Cell Models 

      Cho, Jin A.; Zhang, Xuan; Miller, Gregory M.; Lencer, Wayne I.; Nery, Flavia C. (Public Library of Science, 2014)
      Dystonia is a neurological disorder in which sustained muscle contractions induce twisting and repetitive movements or abnormal posturing. DYT1 early-onset primary dystonia is the most common form of hereditary dystonia ...

    • Analysis of a Mouse Skin Model of Tuberous Sclerosis Complex 

      Guo, Yanan; Dreier, John R.; Cao, Juxiang; Du, Heng; Granter, Scott R.; Kwiatkowski, David J. (Public Library of Science, 2016)
      Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor suppressor gene syndrome in which patients develop several types of tumors, including facial angiofibroma, subungual fibroma, Shagreen patch, angiomyolipomas, ...

    • Analysis of the Effects of Five Factors Relevant to In Vitro Chondrogenesis of Human Mesenchymal Stem Cells Using Factorial Design and High Throughput mRNA-Profiling 

      Jakobsen, Rune B.; Østrup, Esben; Zhang, Xiaolan; Mikkelsen, Tarjei S.; Brinchmann, Jan E. (Public Library of Science, 2014)
      The in vitro process of chondrogenic differentiation of mesenchymal stem cells for tissue engineering has been shown to require three-dimensional culture along with the addition of differentiation factors to the culture ...

    • Applications of sequence coevolution in membrane protein biochemistry 

      Nicoludis, John M.; Gaudet, Rachelle (Elsevier BV, 2018-04)
      Recently, protein sequence coevolution analysis has matured into a predictive powerhouse for protein structure and function. Direct methods, which use global statistical models of sequence coevolution, have enabled the ...

    • Bright and stable luminescent probes for target engagement profiling in live cells 

      Mazitschek, Ralph; Payne, N. Connor; Kalyakina, Alena S.; Singh, Kritika; Tye, Mark (Springer Science and Business Media LLC, 2021-10-21)

    • Cationic Peptide Exposure Enhances Pulsed-Electric-Field-Mediated Membrane Disruption 

      Kennedy, Stephen M.; Aiken, Erik J.; Beres, Kaytlyn A.; Hahn, Adam R.; Kamin, Samantha J.; Hagness, Susan C.; Booske, John H.; Murphy, William L. (Public Library of Science, 2014)
      Background: The use of pulsed electric fields (PEFs) to irreversibly electroporate cells is a promising approach for destroying undesirable cells. This approach may gain enhanced applicability if the intensity of the PEF ...

    • Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling 

      Estrada, Javier; Andrew, Natalie; Gibson, Daniel; Chang, Frederick; Gnad, Florian; Gunawardena, Jeremy (Public Library of Science, 2016)
      The molecular complexity within a cell may be seen as an evolutionary response to the external complexity of the cell’s environment. This suggests that the external environment may be harnessed to interrogate the cell’s ...

    • Co-evolution-based prediction of metal-binding sites in proteomes by machine learning 

      Cheng, Yao; Wang, Haobo; Xu, Hua; Liu, Yuan; Ma, Bin; Chen, Xuemin; Zeng, Xin; Wang, Xianghe; Wang, Bo; Shiau, Carina; Ovchinnikov, Sergey; Su, Xiao-Dong; Wang, Chu (Springer Science and Business Media LLC, 2023-01-02)
      Metal ions play various important biological role in proteins including structural maintenance, molecular recognition and catalysis. Previous methods of predicting metal-binding sites in proteomes were based on either ...

    • Comparison and Optimization of hiPSC Forebrain Cortical Differentiation Protocols 

      Muratore, Christina R.; Srikanth, Priya; Callahan, Dana G.; Young-Pearse, Tracy L. (Public Library of Science, 2014)
      Several protocols have been developed for human induced pluripotent stem cell neuronal differentiation. We compare several methods for forebrain cortical neuronal differentiation by assessing cell morphology, immunostaining ...

    • Cooking shapes the structure and function of the gut microbiome 

      Carmody, Rachel; Bisanz, Jordan E.; Bowen, Benjamin P.; Maurice, Corinne F.; Lyalina, Svetlana; Louie, Katherine B.; Treen, Daniel; Chadaideh, Katia; Maini Rekdal, Vayu; Bess, Elizabeth N.; Spanogiannopoulos, Peter; Ang, Qi Yan; Bauer, Kylynda C.; Balon, Thomas W.; Pollard, Katherine S.; Northen, Trent R.; Turnbaugh, Peter J.; Turnbaugh (Springer Science and Business Media LLC, 2019-09-30)
      Diet is a critical determinant of variation in gut microbial structure and function, outweighing even host genetics. Numerous microbiome studies have compared diets with divergent ingredients, but the everyday practice of ...

    • Crystal Structure of the FERM-SH2 Module of Human Jak2 

      McNally, Randall; Toms, Angela V.; Eck, Michael J. (Public Library of Science, 2016)
      Jak-family tyrosine kinases mediate signaling from diverse cytokine receptors. Binding of Jaks to their cognate receptors is mediated by their N-terminal region, which contains FERM and SH2 domains. Here we describe the ...

    • Derivation of Corneal Keratocyte-Like Cells from Human Induced Pluripotent Stem Cells 

      Naylor, Richard W.; McGhee, Charles N. J.; Cowan, Chad A.; Davidson, Alan J.; Holm, Teresa M.; Sherwin, Trevor (Public Library of Science, 2016)
      Corneal diseases such as keratoconus represent a relatively common disorder in the human population. However, treatment is restricted to corneal transplantation, which only occurs in the most advanced cases. Cell based ...

    • Discovery and molecular basis of subtype-selective cyclophilin inhibitors 

      Peterson, Alexander A.; Rangwala, Aziz M.; Thakur, Manish K.; Ward, Patrick S.; Hung, Christie; Outhwaite, Ian R.; Chan, Alix I.; Usanov, Dmitry L.; Mootha, Vamsi K.; Seeliger, Markus A.; Liu, David (Springer Science and Business Media LLC, 2022-09-26)
      <jats:title>Abstract</jats:title><jats:p>Although cyclophilins are attractive targets for probing biology and therapeutic intervention, no subtype-selective cyclophilin inhibitors have been described. We discovered novel ...

    • Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip 

      Herland, Anna; van der Meer, Andries D.; FitzGerald, Edward A.; Park, Tae-Eun; Sleeboom, Jelle J. F.; Ingber, Donald E. (Public Library of Science, 2016)
      Neurovascular inflammation is a major contributor to many neurological disorders, but modeling these processes in vitro has proven to be difficult. Here, we microengineered a three-dimensional (3D) model of the human ...

    • Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma 

      Kwok, Hui; Freedy, Allyson M.; Siegenfeld, Allison P.; Morriss, Julia W.; Waterbury, Amanda L.; Kissler, Stephen M.; Liau, Brian B. (Springer Science and Business Media LLC, 2023-03-27)
      Drug addiction, a phenomenon where cancer cells paradoxically depend on continuous drug treatment for survival, has uncovered cell signaling mechanisms and cancer co-dependencies. Here, we discover mutations that confer ...

    • Engineered Myosins Drive Filopodial Transport 

      Erdogan, Burcu; Whited, Jessica L. (Springer Science and Business Media LLC, 2021-02-01)
      Engineered, light-inducible artificial myosin motors enable selective and direct manipulation of filopodial extensions and provide refined tools to control intracellular cargo transport in vivo.

    • The Evolution of Quorum Sensing as a Mechanism to Infer Kinship 

      Schluter, Jonas; Schoech, Armin P.; Foster, Kevin R.; Mitri, Sara (Public Library of Science, 2016)
      Bacteria regulate many phenotypes via quorum sensing systems. Quorum sensing is typically thought to evolve because the regulated cooperative phenotypes are only beneficial at certain cell densities. However, quorum sensing ...

    • Functional morphology of the ankle extensor muscle‐tendon units in the springhare Pedetes capensis shows convergent evolution with macropods for bipedal hopping locomotion 

      Veiga, Gabriela N.; Biewener, Andrew; Fuller, Andrea; Ven, Tanja M. F. N.; McGowan, Craig P.; Panaino, Wendy; Snelling, Edward P. (Wiley, 2020-06-25)
      This study assesses the functional morphology of the ankle extensor muscle-tendon units of the springhare Pedetes capensis, an African bipedal hopping rodent, to test for convergent evolution with the Australian bipedal ...

    • General Quantitative Relations Linking Cell Growth and the Cell Cycle in Escherichia Coli 

      Zheng, Hai Tong; Bai, Yang; Jiang, Meiling; Tokuyasu, Taku A.; Huang, Xiongliang; Zhong, Fajun; Wu, Yuqian; Fu, Xiongfei; Kleckner, Nancy; Hwa, Terence; Liu, Chenli (Springer Science and Business Media LLC, 2020-05-18)
      Growth laws emerging from studies of cell populations provide essential constraints on global mechanisms coordinating cell growth. The foundation of bacterial cell cycle studies, based on extensive work done in Escherichia ...

    • A Genetic Strategy for Probing the Functional Diversity of Magnetosome Formation 

      Rahn-Lee, Lilah; Byrne, Meghan E.; Zhang, Manjing; Le Sage, David; Glenn, David R.; Milbourne, Timothy; Walsworth, Ronald L.; Vali, Hojatollah; Komeili, Arash (Public Library of Science, 2015)
      Model genetic systems are invaluable, but limit us to understanding only a few organisms in detail, missing the variations in biological processes that are performed by related organisms. One such diverse process is the ...