Browsing FAS Scholarly Articles by Keyword "DNA sequence analysis"

Now showing items 1-3 of 3

    • Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus 

      Tully, Damien C.; Ogilvie, Colin B.; Batorsky, Rebecca E.; Bean, David J.; Power, Karen A.; Ghebremichael, Musie; Bedard, Hunter E.; Gladden, Adrianne D.; Seese, Aaron M.; Amero, Molly A.; Lane, Kimberly; McGrath, Graham; Bazner, Suzane B.; Tinsley, Jake; Lennon, Niall J.; Henn, Matthew R.; Brumme, Zabrina L.; Norris, Philip J.; Rosenberg, Eric S.; Mayer, Kenneth H.; Jessen, Heiko; Kosakovsky Pond, Sergei L.; Walker, Bruce D.; Altfeld, Marcus; Carlson, Jonathan M.; Allen, Todd M. (Public Library of Science, 2016)
      Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic infection is typically established by a limited number of founder viruses. Elucidation of the precise forces influencing the ...

    • Gene Prediction with Glimmer for Metagenomic Sequences Augmented by Classification and Clustering 

      Kelley, David Roy; Liu, Bo; Delcher, Arthur L.; Pop, Mihai; Salzberg, Steven L. (Oxford University Press, 2011)
      Environmental shotgun sequencing (or metagenomics) is widely used to survey the communities of microbial organisms that live in many diverse ecosystems, such as the human body. Finding the protein-coding genes within the ...

    • Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell 

      Zong, Chenghang; Chapman, Alec Randolph; Xie, Xiaoliang Sunney (American Association for the Advancement of Science, 2012)
      Kindred cells can have different genomes because of dynamic changes in DNA. Single cell sequencing is needed to characterize these genomic differences but has been hindered by whole-genome amplification bias, resulting in ...