Browsing FAS Scholarly Articles by Keyword "Drug Research and Development"

Now showing items 1-4 of 4

    • GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity 

      Fomina-Yadlin, Dina; Kubicek, Stefan; Vetere, Amedeo; He, Kaihui Hu; Schreiber, Stuart L.; Wagner, Bridget K. (Public Library of Science, 2012)
      Background: Expression of insulin in terminally differentiated non-beta cell types in the pancreas could be important to treating type-1 diabetes. Previous findings led us to hypothesize involvement of kinase inhibition ...

    • Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway 

      Li, Gang; Diogo, Dorothee; Wu, Di; Spoonamore, Jim; Dancik, Vlado; Franke, Lude; Kurreeman, Fina; Rossin, Elizabeth Jeffries; Duclos, Grant; Hartland, Cathy; Zhou, Xuezhong; Li, Kejie; Liu, Jun; De Jager, Philip Lawrence; Siminovitch, Katherine A.; Zhernakova, Alexandra; Raychaudhuri, Soumya; Bowes, John; Eyre, Steve; Padyukov, Leonid; Gregersen, Peter K.; Worthington, Jane; Gupta, Namrata; Clemons, Paul A.; Stahl, Eli; Tolliday, Nicola; Plenge, Robert M. (Public Library of Science, 2013)
      Although genetic and non-genetic studies in mouse and human implicate the CD40 pathway in rheumatoid arthritis (RA), there are no approved drugs that inhibit CD40 signaling for clinical care in RA or any other disease. ...

    • Leveraging the Social Determinants of Health: What Works? 

      Taylor, Lauren A.; Tan, Annabel Xulin; Coyle, Caitlin E.; Ndumele, Chima; Rogan, Erika; Canavan, Maureen; Curry, Leslie A.; Bradley, Elizabeth H. (Public Library of Science, 2016)
      We summarized the recently published, peer-reviewed literature that examined the impact of investments in social services or investments in integrated models of health care and social services on health outcomes and health ...

    • Shifts in the Distribution of Mass Densities Is a Signature of Caloric Restriction in Caenorhabditis elegans 

      Reina, Alfonso; Subramaniam, Anand Bala; Laromaine, Anna; Samuel, Aravinthan D. T.; Whitesides, George M. (Public Library of Science, 2013)
      Although the starvation response of the model multicellular organism Caenorhabditis elegans is a subject of much research, there is no convenient phenotypic readout of caloric restriction that can be applicable to large ...