Now showing items 1-5 of 5

    • Genetic Characterization of smg-8 Mutants Reveals No Role in C. elegans Nonsense Mediated Decay 

      Rosains, Jacqueline; Mango, Susan (Public Library of Science, 2012)
      The nonsense mediated decay (NMD) pathway degrades mRNAs bearing premature translation termination codons. In mammals, SMG-8 has been implicated in the NMD pathway, in part by its association with SMG-1 kinase. Here we use ...
    • An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology 

      Fernandes de Abreu, Diana Andrea; Caballero, Antonio; Fardel, Pascal; Stroustrup, Nicholas; Chen, Zhunan; Lee, KyungHwa; Keyes, William D.; Nash, Zachary M.; López-Moyado, Isaac F.; Vaggi, Federico; Cornils, Astrid; Regenass, Martin; Neagu, Anca; Ostojic, Ivan; Liu, Chang; Cho, Yongmin; Sifoglu, Deniz; Shen, Yu; Fontana, Walter; Lu, Hang; Csikasz-Nagy, Attila; Murphy, Coleen T.; Antebi, Adam; Blanc, Eric; Apfeld, Javier; Zhang, Yun; Alcedo, Joy; Ch'ng, QueeLim (Public Library of Science, 2014)
      Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse ...
    • Monoaminergic Orchestration of Motor Programs in a Complex C. elegans Behavior 

      Donnelly, Jamie L.; Clark, Christopher M.; Leifer, Andrew M.; Pirri, Jennifer K.; Haburcak, Marian; Francis, Michael M.; Samuel, Aravinthan DT; Alkema, Mark J. (Public Library of Science, 2013)
      Monoamines provide chemical codes of behavioral states. However, the neural mechanisms of monoaminergic orchestration of behavior are poorly understood. Touch elicits an escape response in Caenorhabditis elegans where the ...
    • A Sexually Conditioned Switch of Chemosensory Behavior in C. elegans 

      Sakai, Naoko; Iwata, Ryo; Yokoi, Saori; Butcher, Rebecca A.; Clardy, Jon; Tomioka, Masahiro; Iino, Yuichi (Public Library of Science, 2013)
      In sexually reproducing animals, mating is essential for transmitting genetic information to the next generation and therefore animals have evolved mechanisms for optimizing the chance of successful mate location. In the ...
    • A Simple Repeat Polymorphism in the MITF-M Promoter Is a Key Regulator of White Spotting in Dogs 

      Baranowska Körberg, Izabella; Sundström, Elisabeth; Meadows, Jennifer R. S.; Rosengren Pielberg, Gerli; Gustafson, Ulla; Hedhammar, Åke; Karlsson, Elinor K.; Seddon, Jennifer; Söderberg, Arne; Vilà, Carles; Zhang, Xiaolan; Åkesson, Mikael; Lindblad-Toh, Kerstin; Andersson, Göran; Andersson, Leif (Public Library of Science, 2014)
      The white spotting locus (S) in dogs is colocalized with the MITF (microphtalmia-associated transcription factor) gene. The phenotypic effects of the four S alleles range from solid colour (S) to extreme white spotting ...