Now showing items 1-5 of 5

    • Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance 

      Ogbunugafor, C. Brandon; Wylie, C. Scott; Diakite, Ibrahim; Weinreich, Daniel M.; Hartl, Daniel L. (Public Library of Science, 2016)
      The adaptive landscape analogy has found practical use in recent years, as many have explored how their understanding can inform therapeutic strategies that subvert the evolution of drug resistance. A major barrier to ...
    • Development of an Optimized Medium, Strain and High-Throughput Culturing Methods for Methylobacterium extorquens 

      Delaney, Nigel Francis; Kaczmarek, Maria E.; Ward, Lewis M.; Swanson, Paige Kathleen; Lee, Ming-Chun; Marx, Christopher J (Public Library of Science, 2013)
      Methylobacterium extorquens strains are the best-studied methylotrophic model system, and their metabolism of single carbon compounds has been studied for over 50 years. Here we develop a new system for high-throughput ...
    • Indirect Evolution of Hybrid Lethality due to Linkage with Selected Locus in Mimulus guttatus 

      Wright, Kevin M.; Lloyd, Deborah; Lowry, David B.; Macnair, Mark R.; Willis, John H. (Public Library of Science, 2013)
      Most species are superbly and intricately adapted to the environments in which they live. Adaptive evolution by natural selection is the primary force shaping biological diversity. Differences between closely related species ...
    • A Spontaneous Mutation in Contactin 1 in the Mouse 

      Davisson, Muriel T.; Bronson, Roderick Terry; Tadenev, Abigail L. D.; Motley, William W.; Krishnaswamy, Arjun Sriram; Seburn, Kevin L.; Burgess, Robert W. (Public Library of Science, 2011)
      Mutations in the gene encoding the immunoglobulin-superfamily member cell adhesion molecule contactin1 (CNTN1) cause lethal congenital myopathy in human patients and neurodevelopmental phenotypes in knockout mice. Whether ...
    • What Is Speciation? 

      Shapiro, B. Jesse; Leducq, Jean-Baptiste; Mallet, James (Public Library of Science, 2016)
      Concepts and definitions of species have been debated by generations of biologists and remain controversial. Microbes pose a particular challenge because of their genetic diversity, asexual reproduction, and often promiscuous ...