Browsing FAS Scholarly Articles by Keyword "Immunodeficiency Viruses"

Now showing items 1-6 of 6

    • Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination 

      Mahan, Alison E.; Jennewein, Madeleine F.; Suscovich, Todd; Dionne, Kendall; Tedesco, Jacquelynne; Chung, Amy W.; Streeck, Hendrik; Pau, Maria; Schuitemaker, Hanneke; Francis, Don; Fast, Patricia; Laufer, Dagna; Walker, Bruce D.; Baden, Lindsey; Barouch, Dan H.; Alter, Galit (Public Library of Science, 2016)
      Antibody effector functions, such as antibody-dependent cellular cytotoxicity, complement deposition, and antibody-dependent phagocytosis, play a critical role in immunity against multiple pathogens, particularly in the ...

    • Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus 

      Tully, Damien C.; Ogilvie, Colin B.; Batorsky, Rebecca E.; Bean, David J.; Power, Karen A.; Ghebremichael, Musie; Bedard, Hunter E.; Gladden, Adrianne D.; Seese, Aaron M.; Amero, Molly A.; Lane, Kimberly; McGrath, Graham; Bazner, Suzane B.; Tinsley, Jake; Lennon, Niall J.; Henn, Matthew R.; Brumme, Zabrina L.; Norris, Philip J.; Rosenberg, Eric S.; Mayer, Kenneth H.; Jessen, Heiko; Kosakovsky Pond, Sergei L.; Walker, Bruce D.; Altfeld, Marcus; Carlson, Jonathan M.; Allen, Todd M. (Public Library of Science, 2016)
      Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic infection is typically established by a limited number of founder viruses. Elucidation of the precise forces influencing the ...

    • Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection 

      Adnan, Sama; Reeves, R. Keith; Gillis, Jacqueline; Wong, Fay E.; Yu, Yi; Camp, Jeremy V.; Li, Qingsheng; Connole, Michelle; Li, Yuan; Piatak, Michael; Lifson, Jeffrey D.; Li, Wenjun; Keele, Brandon F.; Kozlowski, Pamela A.; Desrosiers, Ronald C.; Haase, Ashley T.; Johnson, R. Paul (Public Library of Science, 2016)
      Defining the correlates of immune protection conferred by SIVΔnef, the most effective vaccine against SIV challenge, could enable the design of a protective vaccine against HIV infection. Here we provide a comprehensive ...

    • Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences 

      Tartaglia, Lawrence J.; Chang, Hui-Wen; Lee, Benjamin C.; Abbink, Peter; Ng’ang’a, David; Boyd, Michael; Lavine, Christy L.; Lim, So-Yon; Sanisetty, Srisowmya; Whitney, James B.; Seaman, Michael S.; Rolland, Morgane; Tovanabutra, Sodsai; Ananworanich, Jintanat; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.; Barouch, Dan H. (Public Library of Science, 2016)
      Simian-human immunodeficiency virus (SHIV) challenge stocks are critical for preclinical testing of vaccines, antibodies, and other interventions aimed to prevent HIV-1. A major unmet need for the field has been the lack ...

    • Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV 

      Hill, Alison L.; Rosenbloom, Daniel I. S.; Goldstein, Edward; Hanhauser, Emily; Kuritzkes, Daniel R.; Siliciano, Robert F.; Henrich, Timothy J. (Public Library of Science, 2016)
      Monitoring the efficacy of novel reservoir-reducing treatments for HIV is challenging. The limited ability to sample and quantify latent infection means that supervised antiretroviral therapy (ART) interruption studies are ...

    • Transitioning to Country Ownership of HIV Programs in Rwanda 

      Binagwaho, Agnes; Kankindi, Ida; Kayirangwa, Eugenie; Nyemazi, Jean Pierre; Nsanzimana, Sabin; Morales, Fernando; Kadende-Kaiser, Rose; Scott, Kirstin Woody; Mugisha, Veronicah; Sahabo, Ruben; Baribwira, Cyprien; Isanhart, Leia; Asiimwe, Anita; El-Sadr, Wafaa M.; Raghunathan, Pratima L. (Public Library of Science, 2016)
      Agnes Binagwaho and colleagues describe how Rwanda achieved country ownership of its HIV programs.