Browsing FAS Scholarly Articles by Keyword "Immunology"

Now showing items 1-20 of 30

    • Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination 

      Mahan, Alison E.; Jennewein, Madeleine F.; Suscovich, Todd; Dionne, Kendall; Tedesco, Jacquelynne; Chung, Amy W.; Streeck, Hendrik; Pau, Maria; Schuitemaker, Hanneke; Francis, Don; Fast, Patricia; Laufer, Dagna; Walker, Bruce D.; Baden, Lindsey; Barouch, Dan H.; Alter, Galit (Public Library of Science, 2016)
      Antibody effector functions, such as antibody-dependent cellular cytotoxicity, complement deposition, and antibody-dependent phagocytosis, play a critical role in immunity against multiple pathogens, particularly in the ...

    • Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil 

      Guerrant, Richard L.; Leite, Alvaro M.; Pinkerton, Relana; Medeiros, Pedro H. Q. S.; Cavalcante, Paloma A.; DeBoer, Mark; Kosek, Margaret; Duggan, Christopher; Gewirtz, Andrew; Kagan, Jonathan C.; Gauthier, Anna E.; Swann, Jonathan; Mayneris-Perxachs, Jordi; Bolick, David T.; Maier, Elizabeth A.; Guedes, Marjorie M.; Moore, Sean R.; Petri, William A.; Havt, Alexandre; Lima, Ila F.; Prata, Mara de Moura Gondim; Michaleckyj, Josyf C.; Scharf, Rebecca J.; Sturgeon, Craig; Fasano, Alessio; Lima, Aldo A. M. (Public Library of Science, 2016)
      Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and ...

    • Characterizing the Infection-Induced Transcriptome of Nasonia vitripennis Reveals a Preponderance of Taxonomically-Restricted Immune Genes 

      Sackton, Timothy B.; Werren, John H.; Clark, Andrew G. (Public Library of Science, 2013)
      The innate immune system in insects consists of a conserved core signaling network and rapidly diversifying effector and recognition components, often containing a high proportion of taxonomically-restricted genes. In the ...

    • Comparative Genome Analyses Reveal Distinct Structure in the Saltwater Crocodile MHC 

      Jaratlerdsiri, Weerachai; Deakin, Janine; Godinez, Ricardo M.; Shan, Xueyan; Peterson, Daniel G.; Marthey, Sylvain; Lyons, Eric; McCarthy, Fiona M.; Isberg, Sally R.; Higgins, Damien P.; Chong, Amanda Y.; John, John St; Glenn, Travis C.; Ray, David A.; Gongora, Jaime (Public Library of Science, 2014)
      The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation. The MHC is generally divided into subregions (classes ...

    • Comprehensive Evaluation of Peripheral Nerve Regeneration in the Acute Healing Phase Using Tissue Clearing and Optical Microscopy in a Rodent Model 

      Jung, Yookyung; Ng, Joanna H.; Keating, Cameron P.; Senthil-Kumar, Prabhu; Zhao, Jie; Randolph, Mark A.; Winograd, Jonathan M.; Evans, Conor L. (Public Library of Science, 2014)
      Peripheral nerve injury (PNI), a common injury in both the civilian and military arenas, is usually associated with high healthcare costs and with patients enduring slow recovery times, diminished quality of life, and ...

    • Cooking shapes the structure and function of the gut microbiome 

      Carmody, Rachel; Bisanz, Jordan E.; Bowen, Benjamin P.; Maurice, Corinne F.; Lyalina, Svetlana; Louie, Katherine B.; Treen, Daniel; Chadaideh, Katia; Maini Rekdal, Vayu; Bess, Elizabeth N.; Spanogiannopoulos, Peter; Ang, Qi Yan; Bauer, Kylynda C.; Balon, Thomas W.; Pollard, Katherine S.; Northen, Trent R.; Turnbaugh, Peter J.; Turnbaugh (Springer Science and Business Media LLC, 2019-09-30)
      Diet is a critical determinant of variation in gut microbial structure and function, outweighing even host genetics. Numerous microbiome studies have compared diets with divergent ingredients, but the everyday practice of ...

    • Crystal Structure of the FERM-SH2 Module of Human Jak2 

      McNally, Randall; Toms, Angela V.; Eck, Michael J. (Public Library of Science, 2016)
      Jak-family tyrosine kinases mediate signaling from diverse cytokine receptors. Binding of Jaks to their cognate receptors is mediated by their N-terminal region, which contains FERM and SH2 domains. Here we describe the ...

    • Differential Haemoparasite Intensity between Black Sparrowhawk (Accipiter melanoleucus) Morphs Suggests an Adaptive Function for Polymorphism 

      Lei, Bonnie; Amar, Arjun; Koeslag, Ann; Gous, Tertius A.; Tate, Gareth J. (Public Library of Science, 2013)
      Recent research suggests that genes coding for melanin based colouration may have pleiotropic properties, in particular conveying raised immune function. Thus adaptive function of polymorphism may be associated with parasite ...

    • Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip 

      Herland, Anna; van der Meer, Andries D.; FitzGerald, Edward A.; Park, Tae-Eun; Sleeboom, Jelle J. F.; Ingber, Donald E. (Public Library of Science, 2016)
      Neurovascular inflammation is a major contributor to many neurological disorders, but modeling these processes in vitro has proven to be difficult. Here, we microengineered a three-dimensional (3D) model of the human ...

    • Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction 

      Ayukawa, Shiyu; Kamoshita, Nagisa; Nakayama, Jun; Teramoto, Ryohei; Pishesha, Novalia; Ohba, Kenji; Sato, Nanami; Kozawa, Kei; Abe, Hikari; Semba, Kentaro; Goda, Nobuhito; Fujita, Yasuyuki; Maruyama, Takeshi (Springer Science and Business Media LLC, 2021-10-22)

    • The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification 

      Pukkila-Worley, Read; Feinbaum, Rhonda L.; McEwan, Deborah L.; Conery, Annie L.; Ausubel, Frederick M. (Public Library of Science, 2014)
      Metazoans protect themselves from environmental toxins and virulent pathogens through detoxification and immune responses. We previously identified a small molecule xenobiotic toxin that extends survival of Caenorhabditis ...

    • General Quantitative Relations Linking Cell Growth and the Cell Cycle in Escherichia Coli 

      Zheng, Hai Tong; Bai, Yang; Jiang, Meiling; Tokuyasu, Taku A.; Huang, Xiongliang; Zhong, Fajun; Wu, Yuqian; Fu, Xiongfei; Kleckner, Nancy; Hwa, Terence; Liu, Chenli (Springer Science and Business Media LLC, 2020-05-18)
      Growth laws emerging from studies of cell populations provide essential constraints on global mechanisms coordinating cell growth. The foundation of bacterial cell cycle studies, based on extensive work done in Escherichia ...

    • Germ Cells Are Not Required to Establish the Female Pathway in Mouse Fetal Gonads 

      Maatouk, Danielle M.; Mork, Lindsey; Hinson, Ashley; Kobayashi, Akio; McMahon, Andrew P.; Capel, Blanche (Public Library of Science, 2012)
      The fetal gonad is composed of a mixture of somatic cell lineages and germ cells. The fate of the gonad, male or female, is determined by a population of somatic cells that differentiate into Sertoli or granulosa cells and ...

    • Heat Shock Protein-90 Inhibitors Enhance Antigen Expression on Melanomas and Increase T Cell Recognition of Tumor Cells 

      Haggerty, Timothy J.; Dunn, Ian S.; Rose, Lenora B.; Newton, Estelle E.; Pandolfi, Franco; Kurnick, James T. (Public Library of Science, 2014)
      In an effort to enhance antigen-specific T cell recognition of cancer cells, we have examined numerous modulators of antigen-expression. In this report we demonstrate that twelve different Hsp90 inhibitors (iHsp90) share ...

    • Immunotherapy in the Precision Medicine Era: Melanoma and Beyond 

      Su, Mack Y.; Fisher, David E. (Public Library of Science, 2016)
      In a Perspective, Mack Su and David Fisher discuss the development of immunotherapies for treatment of melanoma and other cancer types.

    • iNKT Cell Production of GM-CSF Controls Mycobacterium tuberculosis 

      Rothchild, Alissa C.; Jayaraman, Pushpa; Nunes-Alves, Cláudio; Behar, Samuel M. (Public Library of Science, 2014)
      Invariant natural killer T (iNKT) cells are activated during infection, but how they limit microbial growth is unknown in most cases. We investigated how iNKT cells suppress intracellular Mycobacterium tuberculosis (Mtb) ...

    • Mechanistic Determinants of the Directionality and Energetics of Active Export by a Heterodimeric ABC Transporter 

      Grossmann, Nina; Vakkasoglu, Ahmet Selim; Hulpke, Sabine; Abele, Rupert; Gaudet, Rachelle; Tampé, Robert (Nature Publishing Group, 2014)
      The ATP-binding cassette (ABC) transporter associated with antigen processing (TAP) participates in immune surveillance by moving proteasomal products into the endoplasmic reticulum (ER) lumen for major histocompatibility ...

    • Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria 

      Daniels, Rachel; Hamilton, Elizabeth J.; Durfee, Katelyn; Ndiaye, Daouda; Wirth, Dyann F.; Hartl, Daniel L.; Volkman, Sarah K. (MyJove Corporation, 2015)
      Despite decades of eradication efforts, malaria remains a global burden. Recent renewed interest in regional elimination and global eradication has been accompanied by increased genomic information about Plasmodium parasite ...

    • A microRNA expression and regulatory element activity atlas of the mouse immune system 

      Rose, Samuel A.; Wroblewska, Aleksandra; Dhainaut, Maxime; Yoshida, Hideyuki; Shaffer, Jonathan M.; Bektesevic, Anela; Ben-Zvi, Benjamin; Rhoads, Andrew; Kim, Edy Y.; Yu, Bingfei; Lavin, Yonit; Merad, Miriam; Buenrostro, Jason D.; Brown, Brian D.; Aguilar, Oscar; Allan, Rhys; Arakawa-Hoyt, Janice; Astarita, Jilian; Austen, K. Frank; Barrett, Nora; Baysoy, Alev; Benoist, Christophe; Buechler, Matthew; Buenrostro, Jason; Casanova, Maria Acebes; Choi, Kyunghee; Chowdhary, Kaitavjeet; Colonna, Marco; Crowl, Ty; Deng, Tianda; Desai, Jigar V.; Desland, Fiona; Ding, Jiarui; Dominguez, Claudia; Dwyer, Daniel; Frascoli, Michela; Gal-Oz, Shani; Goldrath, Ananda; Grieshaber-Bouyer, Ricardo; Jia, Baosen; Johanson, Tim; Jordan, Stefan; Kang, Joonsoo; Kapoor, Varun; Kenigsberg, Ephraim; Kim, Joel; Kim, Ki wook; Kiner, Evgeny; Kronenberg, Mitchell; Lanier, Lewis; Laplace, Catherine; Lareau, Caleb; Leader, Andrew; Lee, Jisu; Magen, Assaf; Maier, Barbara; Maslova, Alexandra; Mathis, Diane; McFarland, Adelle; Meunier, Etienne; Monach, Paul; Mostafavi, Sara; Muller, Soren; Muus, Christoph; Ner-Gaon, Hadas; Nguyen, Quyhn; Nigrovic, Peter A.; Niizuma, Kouta; Novakovsky, German; Nutt, Stephen; Omilusik, Kayla; Ortiz-Lopez, Adriana; Paynich, Mallory; Peng, Vincent; Potempa, Marc; Pradhan, Rachana; Quon, Sara; Ramirez, Ricardo; Ramanan, Deepshika; Randolph, Gwendalyn; Regev, Aviv; Seddu, Kumba; Shay, Tal; Shemesh, Avishai; Shyer, Justin; Smilie, Christopher; Spidale, Nick; Subramanian, Ayshwarya; Sylvia, Katelyn; Tellier, Julie; Turley, Shannon; Vijaykumar, Brinda; Wagers, Amy; Wang, Chendi; Wang, Peter L.; Yang, Liang; Yim, Aldrin (Springer Science and Business Media LLC, 2021-06-07)
      microRNAs (miRNA) play an important role in immune system development and function, often participating in regulatory networks with the transcription factors that drive their expression. However, many of these relationships ...

    • Minimally Symptomatic Infection in an Ebola ‘Hotspot’: A Cross-Sectional Serosurvey 

      Richardson, Eugene T.; Kelly, J. Daniel; Barrie, Mohamed Bailor; Mesman, Annelies W.; Karku, Sahr; Quiwa, Komba; Marsh, Regan H.; Koedoyoma, Songor; Daboh, Fodei; Barron, Kathryn P.; Grady, Michael; Tucker, Elizabeth; Dierberg, Kerry L.; Rutherford, George W.; Barry, Michele; Jones, James Holland; Murray, Megan B.; Farmer, Paul E. (Public Library of Science, 2016)
      Introduction: Evidence for minimally symptomatic Ebola virus (EBOV) infection is limited. During the 2013–16 outbreak in West Africa, it was not considered epidemiologically relevant to published models or projections of ...