Browsing FAS Scholarly Articles by Keyword "antiproliferative"

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    • Enantioselective Synthesis of (+)-Cephalostatin 1 

      Fortner, Kevin; Kato, Darryl; Tanaka, Yoshiki; Shair, Matthew David (American Chemical Society, 2010)
      This Article describes an enantioselective synthesis of cephalostatin 1. Key steps of this synthesis are a unique methyl group selective allylic oxidation, directed C−H hydroxylation of a sterol at C12, Au(I)-catalyzed ...

    • A Multiply Convergent Platform for the Synthesis of Trioxacarcins 

      Švenda, Jakub; Hill, Nicholas; Myers, Andrew G. (United States National Academy of Sciences, 2011)
      Many first-line cancer drugs are natural products or are derived from them by chemical modification. The trioxacarcins are an emerging class of molecules of microbial origin with potent antiproliferative effects, which may ...