Browsing FAS Scholarly Articles by Keyword "carbon-11"
Now showing items 1-6 of 6
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Evaluation of [11C]metergoline as a PET Radiotracer for 5HTR in Nonhuman Primates
(Elsevier BV, 2010)Metergoline, a serotonin receptor antagonist, was labeled with carbon-11 in order to evaluate its pharmacokinetics and distribution in non-human primates using positron emission tomography. [11C]Metergoline had moderate ... -
Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, A Calcium Channel Antagonist
(2016)In the interest of developing in vivo positron emission tomography (PET) probes for neuroimaging of calcium channels, we have prepared a carbon-11 isotopologue of a dihydropyridine Ca2+-channel antagonist, isradipine. ... -
Radiosynthesis and Evaluation of [11C]EMPA as a Potential PET Tracer for Orexin 2 Receptors
(Elsevier BV, 2013)EMPA is a selective antagonist of orexin 2 (OX2) receptors. Previous literature with [3H]-EMPA suggest that it may be used as an imaging agent for OX2 receptors; however, brain penetration is known to be modest. To evaluate ... -
Synthesis and Evaluation of Methylated Arylazepine Compounds for PET Imaging of 5-HT 2c Receptors
(American Chemical Society (ACS), 2013)The serotonin 5-HT2c receptor is implicated in a number of diseases including obesity, depression, anxiety, and schizophrenia. In order to ascribe the role of 5-HT2c in these diseases, a method for measuring 5-HT2c density ... -
Synthesis and Preclinical Evaluation of Sulfonamido-based [11C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase
(Ivyspring International Publisher, 2016)Monoacylglycerol lipase (MAGL) is a 33 kDa member of the serine hydrolase superfamily that preferentially degrades 2-arachidonoylglycerol (2-AG) to arachidonic acid in the endocannabinoid system. Inhibition of MAGL is not ... -
Synthesis of [\(^{11}\)C]SSR149415 and Preliminary Imaging Studies Using Positron Emission Tomography
(Elsevier BV, 2010)SSR149415 was the first non-peptide vasopressin-(V\(_{1b}\)) receptor antagonist reported. It has been used to probe the role of V\(_{1b}\) receptors in animal models of depression, aggression, and stress-anxiety, and was ...