Now showing items 1-2 of 2

    • Comparative Lesion Sequencing Provides Insights into Tumor Evolution 

      Jones, Siân; Chen, Wei-dong; Parmigiani, Giovanni; Diehl, Frank; Beerenwinkel, Niko; Antal, Tibor; Traulsen, Arne; Nowak, Martin A.; Siegel, Christopher; Velculescu, Victor E.; Kinzler, Kenneth W.; Vogelstein, Bert; Willis, Joseph; Markowitz, Sanford D. (Proceedings of the National Academy of Sciences, 2008)
      We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses ...
    • Inhibition of Oncogenic Wnt Signaling through Direct Targeting of β-Catenin 

      Grossmann, Tom N.; Yeh, Johannes Johannes; Bowman, Brian R.; Chu, Qian; Moellering, Raymond E.; Verdine, Gregory L. (Proceedings of the National Academy of Sciences, 2012)
      Aberrant activation of signaling by the Wnt pathway is strongly implicated in the onset and progression of numerous types of cancer. Owing to the persistent dependence of these tumors on Wnt signaling for growth and survival, ...