Browsing FAS Scholarly Articles by Keyword "endoderm"

Now showing items 1-3 of 3

    • Generation of pluripotent stem cells from patients with type 1 diabetes 

      Maehr, René; Chen, Shuibing; Snitow, Melinda; Ludwig, Thomas; Yagasaki, Lisa; Goland, Robin; Leibel, Rudolph L.; Melton, Douglas A. (Proceedings of the National Academy of Sciences, 2009)
      Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would ...

    • Genetic Targeting of the Endoderm with Claudin-6CreER 

      Anderson, William J.; Zhou, Qiao; Alcalde, Victor; Kaneko, Osamu F; Blank, Leah J; Sherwood, Richard Irving; Guseh, James Sawalla; Rajagopal, Jayaraj; Melton, Douglas A. (Wiley-Blackwell, 2008)
      A full description of the ontogeny of the β cell would guide efforts to generate β cells from embryonic stem cells (ESCs). The first step requires an understanding of definitive endoderm: the genes and signals responsible ...

    • Transcriptional dynamics of endodermal organ formation 

      Sherwood, Richard I.; Chen, Tzong-Yang Albert; Melton, Douglas A. (Wiley Blackwell (John Wiley & Sons), 2009)
      Although endodermal organs including the liver, pancreas, and intestine are of significant therapeutic interest, the mechanism by which the endoderm is divided into organ domains during embryogenesis is not well understood. ...