Browsing FAS Scholarly Articles by Keyword "evolutionary modeling"

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    • Evolution under Fluctuating Environments Explains Observed Robustness in Metabolic Networks 

      Soyer, Orkun S.; Pfeiffer, Thomas (Public Library of Science, 2010)
      A high level of robustness against gene deletion is observed in many organisms. However, it is still not clear which biochemical features underline this robustness and how these are acquired during evolution. One hypothesis, ...

    • Optimal Drug Synergy in Antimicrobial Treatments 

      Torella, Joseph; Chait, Remy Paul; Kishony, Roy (Public Library of Science, 2010)
      The rapid proliferation of antibiotic-resistant pathogens has spurred the use of drug combinations to maintain clinical efficacy and combat the evolution of resistance. Drug pairs can interact synergistically or antagonistically, ...