Browsing FAS Scholarly Articles by Keyword "malaria"
Now showing items 1-9 of 9
-
Characterization and Structural Studies of the Plasmodium Falciparum Ubiquitin and Nedd8 Hydrolase UCHL3
(American Society for Biochemistry and Molecular Biology, 2010)Like their human hosts, Plasmodium falciparum parasites rely on the ubiquitin-proteasome system for survival. We previously identified PfUCHL3, a deubiquitinating enzyme, and here we characterize its activity and changes ... -
Compensatory Mutations Restore Fitness During the Evolution of Dihydrofolate Reductase
(Oxford University Press, 2010)Whether a trade-off exists between robustness and evolvability is an important issue for protein evolution. While traditional viewpoints have assumed that existing functions must be compromised by the evolution of novel ... -
Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria
(AmericanChemical Society, 2011)Here, we describe the discovery of a novel antimalarial agent using phenotypic screening of Plasmodium falciparum asexual blood-stage parasites. Screening a novel compound collection created using diversity-oriented synthesis ... -
Early-Life Malaria Exposure and Adult Outcomes: Evidence from Malaria Eradication in India
(American Economic Association, 2010)We examine the effects of exposure to malaria in early childhood on educational attainment and economic status in adulthood by exploiting geographic variation in malaria prevalence in India prior to a nationwide eradication ... -
Erwin H. Ackerknecht: Social Medicine and the History of Medicine
(Johns Hopkins University Press, 2007)Erwin H. Ackerknecht was an influential member of that small group of largely émigré historians of medicine who professionalized their field in the United States. Ackerknecht was influenced by both contemporary social ... -
The Evolution of the Anopheles 16 Genomes Project
(Genetics Society of America, 2013)We report the imminent completion of a set of reference genome assemblies for 16 species of Anopheles mosquitoes. In addition to providing a generally useful resource for comparative genomic analyses, these genome sequences ... -
A Global Transcriptional Analysis of Plasmodium Falciparum Malaria Reveals A Novel Family of Telomere-Associated lncRNAs
(BioMed Central, 2011)Background: Mounting evidence suggests a major role for epigenetic feedback in Plasmodium falciparum transcriptional regulation. Long non-coding RNAs (lncRNAs) have recently emerged as a new paradigm in epigenetic ... -
Glycophorin B is the Erythrocyte Receptor of Plasmodium Falciparum Erythrocyte-Binding Ligand, EBL-1
(National Academy of Sciences, 2009)In the war against Plasmodium, humans have evolved to eliminate or modify proteins on the erythrocyte surface that serve as receptors for parasite invasion, such as the Duffy blood group, a receptor for Plasmodium vivax, ... -
Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria
(MyJove Corporation, 2015)Despite decades of eradication efforts, malaria remains a global burden. Recent renewed interest in regional elimination and global eradication has been accompanied by increased genomic information about Plasmodium parasite ...