Browsing FAS Scholarly Articles by Keyword "mass spectrometry"
Now showing items 1-5 of 5
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A Chemical Screen for Biological Small Molecule-RNA Conjugates Reveals CoA-Linked RNA
(National Academy of Sciences, 2009)Compared with the rapidly expanding set of known biological roles for RNA, the known chemical diversity of cellular RNA has remained limited primarily to canonical RNA, 3'-aminoacylated tRNAs, nucleobase-modified RNAs, and ... -
Hardware-Accelerated 3D Visualization of Mass Spectrometry Data
(Institute of Electrical and Electronics Engineers, 2005)We present a system for three-dimensional visualization of complex Liquid Chromatography - Mass Spectrometry (LCMS) data. Every LCMS data point has three attributes: time, mass, and intensity. Instead of the traditional ... -
Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability
(American Chemical Society, 2010)This paper combines two techniques—mass spectrometry and protein charge ladders—to examine the relationship between the surface charge and hydrophobicity of a protein (bovine carbonic anhydrase II; BCA II) and its rate of ... -
Screening of DUB activity and specificity by MALDI-TOF mass spectrometry
(2014)Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. ... -
Synthesis of an electronically-tuned minimally interfering alkynyl photo-affinity label to measure small molecule–protein interactions
(Elsevier BV, 2018-06)We report the synthesis of an electronically-tuned minimally interfering photo-affinity label (MI-PAL), a compact five-carbon tag functionalized with an alkyl diazirine and alkyne handle. MI-PAL is compatible with protein ...