Browsing FAS Scholarly Articles by Keyword "mechanotransduction"

Now showing items 1-5 of 5

    • Blast-induced phenotypic switching in cerebral vasospasm 

      Alford, Patrick W.; Dabiri, Borna Esfahani; Goss, Josue; Hemphill, Matthew Allen; Brigham, Mark Daniel; Parker, Kevin Kit (Proceedings of the National Academy of Sciences, 2011)
      Vasospasm of the cerebrovasculature is a common manifestation of blast-induced traumatic brain injury (bTBI) reported among combat casualties in the conflicts in Afghanistan and Iraq. Cerebral vasospasm occurs more frequently, ...

    • A Mechanosensitive Transcriptional Mechanism That Controls Angiogenesis 

      Mammoto, Akiko; Connor, Kip; Mammoto, Tadanori; Yung, Chong W.; Huh, Dongeun; Aderman, Christopher Michael; Mostoslavsky, Gustavo; Smith, Lois Elaine Hodgson; Ingber, Donald Elliott (Nature Publishing Group, 2009)
      Angiogenesis is controlled by physical interactions between cells and extracellular matrix as well as soluble angiogenic factors, such as VEGF. However, the mechanism by which mechanical signals integrate with other ...

    • A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15 

      Powers, Robert E.; Gaudet, Rachelle; Sotomayor, Marcos (Elsevier BV, 2017)
      Tip links of the inner ear are protein filaments essential for hearing and balance. Two atypical cadherins, cadherin-23 and protocadherin-15, interact in a Ca2+-dependent manner to form tip links. The largely unknown ...

    • Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip 

      McCain, M. L.; Sheehy, Sean Paul; Grosberg, A.; Goss, J. A.; Parker, Kevin Kit (Proceedings of the National Academy of Sciences, 2013)
      The lack of a robust pipeline of medical therapeutic agents for the treatment of heart disease may be partially attributed to the lack of in vitro models that recapitulate the essential structure–function relationships of ...

    • Sorting Out a Promiscuous Superfamily: Towards Cadherin Connectomics 

      Sotomayor, Marcos; Gaudet, Rachelle; Corey, David Paul (Elsevier BV, 2014)
      Members of the cadherin superfamily of proteins are involved in diverse biological processes such as morphogenesis, sound transduction, and neuronal connectivity. Key to cadherin function is their extracellular domain ...