Browsing FAS Scholarly Articles by Keyword "mitosis"

Now showing items 1-5 of 5

    • Developing Cell Biology 

      Needleman, Daniel Joseph (eLife Sciences Publications, Ltd, 2013)
      Experiments in Xenopus embryo extracts reveal that changes in cellular biochemistry cause mitotic spindles to decrease in size over the course of early development.

    • Recipient Cell Nuclear Factors Are Required for Reprogramming by Nuclear Transfer 

      Egli, Dieter; Eggan, Kevin Carl (Company of Biologists, 2010)
      Nuclear transfer allows the reprogramming of somatic cells to totipotency. The cell cycle state of the donor and recipient cells, as well as their extent of differentiation, have each been cited as important determinants ...

    • Recruiting a Microtubule-Binding Complex to DNA Directs Chromosome Segregation in Budding Yeast 

      Lacefield, Soni; Lau, Tsz Cham Derek; Murray, Andrew W. (Natur Publishing Group, 2009)
      Accurate chromosome segregation depends on the kinetochore, the complex of proteins that link microtubules to centromeric DNA1. The budding yeast kinetochore consists of more than 80 proteins assembled on a 125bp region ...

    • Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1 

      Erikson, Raymond Leo (National Academy of Sciences, 2011-06-28)
      Bipolar spindle formation is pivotal for accurate segregation of mitotic chromosomes during cell division. A growing body of evidence suggests that, in addition to centrosome- and chromatin-based microtubule (MT) nucleation, ...

    • Reprogramming within Hours Following Nuclear Transfer into Mouse but not Human Zygotes 

      Egli, Dieter; Chen, Alice E.; Saphier Belfer, Genevieve C; Ichida, Justin; Fitzgerald, Claire; Go, Kathryn J.; Acevedo, Nicole; Patel, Jay; Baetscher, Manfred; Kearns, William G.; Goland, Robin; Leibel, Rudolph L.; Melton, Douglas A.; Eggan, Kevin Carl (Nature Publishing Group, 2011)
      Fertilized mouse zygotes can reprogram somatic cells to a pluripotent state. Human zygotes might therefore be useful for producing patient-derived pluripotent stem cells. However, logistical, legal and social considerations ...