Now showing items 1-2 of 2

    • NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1 

      Ersing, Ina; Bernhardt, Katharina; Gewurz, Benjamin E. (MDPI, 2013)
      The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive ...
    • Screening of DUB activity and specificity by MALDI-TOF mass spectrometry 

      Ritorto, Maria Stella; Ewan, Richard; Perez-Oliva, Ana B.; Knebel, Axel; Buhrlage, Sara J.; Wightman, Melanie; Kelly, Sharon M.; Wood, Nicola T.; Virdee, Satpal; Gray, Nathanael S.; Morrice, Nicholas A.; Alessi, Dario R.; Trost, Matthias (2014)
      Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. ...