Body fat, energy balance and estradiol levels: a study based on hormonal profiles from complete menstrual cycles

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Body fat, energy balance and estradiol levels: a study based on hormonal profiles from complete menstrual cycles

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dc.contributor.author Thune, Inger
dc.contributor.author Ziomkiewicz, Anna
dc.contributor.author Ellison, Peter
dc.contributor.author Lipson, Susan F.
dc.contributor.author Jasienska, Grazyna
dc.date.accessioned 2009-02-09T16:33:06Z
dc.date.issued 2008
dc.identifier.citation Ziomkiewicz, Anna, Peter T. Ellison, Susan F. Lipson, Inger Thune, and Graznya Jasienska. 2008. Body fat, energy balance, and estradiol levels: a study based on hormonal profiles from complete menstrual cycles. Human Reproduction 23(11): 2555-2563. en
dc.identifier.issn 0268-1161 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:2579735
dc.description.abstract BACKGROUND: Female fecundity is regulated by nutritional status. Although widely cited, this hypothesis is not strongly supported by empirical data from non-obese, healthy women of reproductive age. METHODS: Healthy, reproductive aged women (n = 141) from Southern Poland collected daily morning saliva samples for one complete menstrual cycle. Levels of 17-b-estradiol were analyzed by radioimmunoassay. Anthropometric measurements, including body fat percentage, were taken randomly with respect to phase of the menstrual cycle. Energy balance was specified based on changes in body fat percentage from the beginning to the end of the observation period. RESULTS: Women with very low and high body fat had significantly lower levels of E2 compared with women with low and average body fat. In women of very low to average body fat, a 10% increase in body fat was associated with a 5 – 7 pmol/l increase in estradiol levels. The association between fat percentage and E2 was even stronger in women with positive energy balance, who also showed significant differences between body fat groups in estradiol profiles across whole the menstrual cycle. No such relationship was found in women with negative energy balance. CONCLUSIONS: In healthy women, we found a non-linear association between body fat and estradiol levels. Both very low and high body fat was associated with decreased estradiol levels. The relationship between estradiol and body fat was strongly influenced by women’s energy balance. en
dc.description.sponsorship Anthropology en
dc.description.sponsorship Human Evolutionary Biology
dc.publisher Oxford University Press en
dc.relation.isversionof http://dx.doi.org/10.1093/humrep/den213 en
dash.license LAA
dc.title Body fat, energy balance and estradiol levels: a study based on hormonal profiles from complete menstrual cycles en
dc.relation.journal Human Reproduction en
dash.depositing.author Ellison, Peter

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  • FAS Scholarly Articles [6929]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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