17-beta-Estradiol in relation to age at menarche and adult obesity in premenopausal women

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17-beta-Estradiol in relation to age at menarche and adult obesity in premenopausal women

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dc.contributor.author Hjartaker, Anette
dc.contributor.author Ballard-Barbash, Rachel
dc.contributor.author Veierød, Marti B.
dc.contributor.author Emaus, Aina
dc.contributor.author Ellison, Peter
dc.contributor.author Thune, Inger
dc.contributor.author Furberg, Anne-Sofie
dc.contributor.author Espetvedt, Sissi
dc.contributor.author Jasienska, Grazyna
dc.date.accessioned 2009-02-12T04:12:38Z
dc.date.issued 2007
dc.identifier.citation Emaus, Aina, Sissi Espetvedt, Marti B. Veierød, Rachel Ballard-Barbash, Anne-Sofie Furberg, Peter T. Ellison, Grazyna Jasienska, Anette Hjartåker, and Inger Thune. 2007. 17-β-estradiol in relation to age at menarche at menarche and adult obesity in premenopausal women. Human Reproduction 23(4): 919-927. en
dc.identifier.issn 0268-1161 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:2585485
dc.description.abstract BACKGROUND: We hypothesize that premenopausal endogenous estradiol may be associated with age at menarche and adult overweight and obesity, potentially contributing to breast cancer risk. METHODS: We assessed age at menarche by questionnaire among 204 healthy Norwegian women, aged 25 – 35 years. Measures of body composition included body mass index (BMI, kg/m2), waist circumference (WC, cm), waist-to-hip ratio (WHR) and fat percentage dual energy X-ray absorptiometry, (DEXA). Daily salivary 17-b-estradiol (E2) concentrations were collected throughout one entire menstrual cycle and assessed by radioimmunoassay (RIA). Linear regression analyses and linear mixed models for repeated measures were used and potential confounding factors and effect modifiers were tested. RESULTS: Among women with an early age at menarche (12 years), the overall mean salivary E2 concentration increased by 3.7 pmol/l (95% confidence interval, 1.8 – 5.7 pmol/l) with each 9.8 cm (1 SD) increase in WC, which represents a 20.7% change in the mean for the total group. Among the same early maturers, a 1 SD (0.06) change in WHR was directly associated with a 24.0% change in mean E2 concentration for the total group. CONCLUSIONS: Our findings support the hypothesis that early age at menarche, together with adult overweight and obesity, result in high levels of 17-b-estradiol throughout the menstrual cycle. en
dc.description.sponsorship Anthropology en
dc.description.sponsorship Human Evolutionary Biology
dc.language.iso en_US en
dc.publisher Oxford University Press en
dc.relation.isversionof http://dx.doi.org/10.1093/humrep/dem432 en
dash.license LAA
dc.subject 17-β-estradiol en
dc.subject adult body fatness en
dc.subject breast cancer risk en
dc.subject Norway en
dc.subject age at menarche en
dc.title 17-beta-Estradiol in relation to age at menarche and adult obesity in premenopausal women en
dc.relation.journal Human Reproduction en
dash.depositing.author Ellison, Peter

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  • FAS Scholarly Articles [7470]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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