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dc.contributor.authorProcko, Erik
dc.contributor.authorGaudet, Rachelle
dc.date.accessioned2009-02-20T15:22:36Z
dc.date.issued2009
dc.identifier.citationProcko, Erik, and Rachelle Gaudet. Forthcoming. Antigen processing and presentation: TAPping into ABC transporters. Current Opinion in Immunology.en
dc.identifier.issn0952-7915en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:2624506
dc.description.abstractAdaptive, cell-mediated immunity involves the presentation of antigenic peptides on class I MHC molecules at the cell surface. This requires an ABC transporter associated with antigen processing (TAP) to transport antigenic peptides generated in the cytosol into the endoplasmic reticulum (ER) for loading onto class I MHC. Recent crystal structures of bacterial ABC transporters suggest how the transmembrane domains of TAP form a peptide-binding cavity that acquires peptides from the cytosol, and following ATP-induced conformational changes, the peptide-binding cavity closes to the cytosol and instead opens to the ER lumen for peptide release. Extensive biochemical studies show how transport is driven by ATP binding and hydrolysis on an asymmetric pair of cytosolic nucleotide-binding domains, which are physically coupled to the peptide binding site to propagate conformational changes through the protein.en
dc.description.sponsorshipMolecular and Cellular Biologyen
dc.language.isoen_USen
dc.publisherElsevieren
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.coi.2009.02.003en
dash.licenseLAA
dc.titleAntigen Processing and Presentation: TAPping into ABC Transportersen
dc.relation.journalCurrent Opinion in Immunologyen
dash.depositing.authorGaudet, Rachelle
dc.identifier.doi10.1016/j.coi.2009.02.003*
dash.contributor.affiliatedGaudet, Rachelle


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