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dc.contributor.author	Colwell, Lucy J.
dc.contributor.author	Brenner, Michael
dc.date.accessioned	2009-03-27T18:28:15Z
dc.date.issued	2009
dc.identifier.citation	Colwell, Lucy J. and Michael P. Brenner. 2009. Action potential initiation in the Hodgkin-Huxley Model. PLoS Computational Biololgy 5(1): e1000265.	en
dc.identifier.issn	1553-734X	en
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:2757252
dc.description.abstract	A recent paper of B. Naundorf et al. described an intriguing negative correlation between variability of the onset potential at which an action potential occurs (the onset span) and the rapidity of action potential initiation (the onset rapidity). This correlation was demonstrated in numerical simulations of the Hodgkin-Huxley model. Due to this antagonism, it is argued that Hodgkin-Huxley-type models are unable to explain action potential initiation observed in cortical neurons <i>in vivo</i> or <i>in vitro</i>. Here we apply a method from theoretical physics to derive an analytical characterization of this problem. We analytically compute the probability distribution of onset potentials and analytically derive the inverse relationship between onset span and onset rapidity. We find that the relationship between onset span and onset rapidity depends on the level of synaptic background activity. Hence we are able to elucidate the regions of parameter space for which the Hodgkin-Huxley model is able to accurately describe the behavior of this system.	en
dc.description.sponsorship	Engineering and Applied Sciences	en
dc.language.iso	en_US	en
dc.publisher	Public Library of Science	en
dc.relation.isversionof	http://dx.doi.org/10.1371/journal.pcbi.1000265	en
dash.license	OAP
dc.title	Action Potential Initiation in the Hodgkin-Huxley Model	en
dc.relation.journal	PLoS Computational Biology	en
dash.depositing.author	Brenner, Michael

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  Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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