The brachymorph mouse and human evolution

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The brachymorph mouse and human evolution

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dc.contributor.author Brown, Jevon J. Y.
dc.contributor.author Hallgrimsson, Benedikt
dc.contributor.author Jirik, Frank R.
dc.contributor.author Ford-Hutchinson, A.
dc.contributor.author Lieberman, Daniel
dc.date.accessioned 2009-04-21T02:13:38Z
dc.date.issued 2005
dc.identifier.citation Brown, Jevon J. Y., A. Ford-Hutchinson, Frank R. Jirik, Daniel E. Lieberman, Benedikt Hallgrimsson. 2005. The brachymorph mouse and human evolution. American Journal of Physical Anthropology 126(S40): 79. en
dc.identifier.issn 0002-9483 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:2797437
dc.description.abstract The degree to which evolutionary change in the cranial base was an integrative influence on other aspects of craniofacial evolution in hominids is a subject of much debate. Using a mouse model, we test the hypothesis that a mutation which produced a shortening of the cranial base creates some of the same changes seen in hominid evolution, such as increased cranial flexion, retraction of the face and increased neurocranial height. The Brachymorph (bm) mutant mice posses an autosomal recessive mutation that affects the sulfation of cartilage matrix glycosaminoglycans, initiating hyper-ossification and stunting of endochondral bone. In the cranium, this produces a reduction of the size of the basicranium. We obtained 3D reconstructions of brachymorph mutants (N=21) and wildtype littermates (N=19) using computed microtomography and performed morphometric analysis of 3D landmarks. Principal components analysis of Procrustes coordinates for the combined sample revealed a clear separation in shape for the two groups as well as shape variation consistent with the hypothesis. Euclidean distance matrix analysis revealed that the Brachymorph mutants had a significantly shorter (>10%) cranial base (at p=.05), as well as a significant increase in neurocranial height (>10%). We also found a significant increase in both cranial base flexion (t=3.899, df=25, p<<.05) and facial retraction (t=-3.157, df=24, p<<.05). These results demonstrate that the Brachymorph mutation produces cranial characteristics that mirror some of the changes seen in hominid evolution. This study provides evidence, in the mouse model, which suggests an integrative role for the basicranium in human evolution. en
dc.description.sponsorship Anthropology en
dc.description.sponsorship Human Evolutionary Biology
dc.language.iso en_US en
dc.publisher John Wiley & Sons en
dc.relation.isversionof http://dx.doi.org/10.1002/ajpa.20217 en
dash.license LAA
dc.title The brachymorph mouse and human evolution en
dc.relation.journal American Journal of Physical Anthropology en
dash.depositing.author Lieberman, Daniel

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  • FAS Scholarly Articles [6885]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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