Analyses Do Not Support CYP17 Genotype-Estradiol Associations--In Response

Analyses Do Not Support CYP17 Genotype-Estradiol Associations--In Response

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Analyses Do Not Support CYP17 Genotype-Estradiol Associations--In Response

dc.contributor.author	Ellison, Peter
dc.contributor.author	Jasienska, Grazyna
dc.date.accessioned	2009-05-04T14:40:40Z
dc.date.issued	2008
dc.identifier.citation	Jasienska, Grazyna and Peter T. Ellison. 2008. Analyses do not support CYP17 genotype-estradiol associations - In response. Cancer Epidemiology Biomarkers and PreventioN 17(6): 1550.	en
dc.identifier.issn	1055-9965	en
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:2894777
dc.description.abstract	In Response: Vitzthum and Thornburg’s comments seem to reflect a basic misunderstanding of our paper and its results. As noted in the title of the article, we document an association between CYP17 genotypes and salivary estradiol levels. Variation in follicular steroidogenesis, up to and including ovulatory failure, is precisely the variation we are studying. To remove anovulatory cycles from the sample would be to remove a principal source of variance in estradiol levels between women, a source of variation with direct implications for breast cancer risk. Vitzthum and Thornburg are also incorrect in their assertion that our statistical methods are flawed. In the repeated-measures ANOVA, the univariate F statistic may be safely used when accompanied by appropriate adjustments (Geisser-Greenhouse and Huynh-Feldt) to the degrees of freedom (even if the sphericity requirement is not met). In the article, we provided P values obtained under both types of adjustment. Our use of the Wilcoxon signed-rank test adhered strictly to the assumptions specified in the principal textbook of biostatistical methods by Sokal and Rohlf (2).	en
dc.description.sponsorship	Anthropology	en
dc.description.sponsorship	Human Evolutionary Biology
dc.language.iso	en_US	en
dc.publisher	American Association for Cancer Research	en
dc.relation.isversionof	http://dx.doi.org/10.1158/1055-9965.EPI-08-0398	en
dash.license	OAP
dc.title	Analyses Do Not Support CYP17 Genotype-Estradiol Associations--In Response	en
dc.relation.journal	Cancer Epidemiology Biomarkers and Prevention	en
dash.depositing.author	Ellison, Peter