Analyses Do Not Support CYP17 Genotype-Estradiol Associations--In Response

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Analyses Do Not Support CYP17 Genotype-Estradiol Associations--In Response

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dc.contributor.author Ellison, Peter
dc.contributor.author Jasienska, Grazyna
dc.date.accessioned 2009-05-04T14:40:40Z
dc.date.issued 2008
dc.identifier.citation Jasienska, Grazyna and Peter T. Ellison. 2008. Analyses do not support CYP17 genotype-estradiol associations - In response. Cancer Epidemiology Biomarkers and PreventioN 17(6): 1550. en
dc.identifier.issn 1055-9965 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:2894777
dc.description.abstract In Response: Vitzthum and Thornburg’s comments seem to reflect a basic misunderstanding of our paper and its results. As noted in the title of the article, we document an association between CYP17 genotypes and salivary estradiol levels. Variation in follicular steroidogenesis, up to and including ovulatory failure, is precisely the variation we are studying. To remove anovulatory cycles from the sample would be to remove a principal source of variance in estradiol levels between women, a source of variation with direct implications for breast cancer risk. Vitzthum and Thornburg are also incorrect in their assertion that our statistical methods are flawed. In the repeated-measures ANOVA, the univariate F statistic may be safely used when accompanied by appropriate adjustments (Geisser-Greenhouse and Huynh-Feldt) to the degrees of freedom (even if the sphericity requirement is not met). In the article, we provided P values obtained under both types of adjustment. Our use of the Wilcoxon signed-rank test adhered strictly to the assumptions specified in the principal textbook of biostatistical methods by Sokal and Rohlf (2). en
dc.description.sponsorship Anthropology en
dc.description.sponsorship Human Evolutionary Biology
dc.language.iso en_US en
dc.publisher American Association for Cancer Research en
dc.relation.isversionof http://dx.doi.org/10.1158/1055-9965.EPI-08-0398 en
dash.license OAP
dc.title Analyses Do Not Support CYP17 Genotype-Estradiol Associations--In Response en
dc.relation.journal Cancer Epidemiology Biomarkers and Prevention en
dash.depositing.author Ellison, Peter

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  • FAS Scholarly Articles [7289]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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