17β-Estradiol Levels During An Entire Menstrual Cycle In Response To Adult Stature and Insulin, Of Possible Importance For Breast Cancer Risk: The EBBA-I study.

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17β-Estradiol Levels During An Entire Menstrual Cycle In Response To Adult Stature and Insulin, Of Possible Importance For Breast Cancer Risk: The EBBA-I study.

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dc.contributor.author Furberg, Anne-Sofie
dc.contributor.author Wist, Erik
dc.contributor.author Espetvedt, Sissi E.
dc.contributor.author Ellison, Peter
dc.contributor.author Jasienska, Grazyna
dc.contributor.author Emaus, Aina
dc.contributor.author Thune, Inger
dc.contributor.author Tretli, Steinar
dc.date.accessioned 2009-05-29T14:42:51Z
dc.date.issued 2009
dc.identifier.citation Espetvedt, Sissi, Aina Emaus, Steinar Tretli, Grazyna Jasienska, Peter T. Ellison, Anne-Sofie Furberg, Erik Wist, and Inger Thune. 2009. 17β-estradiol levels during an entire menstrual cycle in response to adult stature and insulin, of possible importance for breast cancer risk: The EBBA-I study. CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts. Cancer Research 69(2)(Supplement): 273S-274S. en
dc.identifier.issn 0008-5472 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:3008263
dc.description.abstract Background: The normal breast cells develop into malignant cells as a result of a complex interplay between genetic, environmental, nutritional and hormonal factors. Attained adult stature and insulin levels, risk factors for breast cancer, may also vary in response to the same factors. Thus, we hypothesize that 17β-estradiol, a key factor in the carcinogenesis of the breast, may vary in response to adult height in combination with insulin levels of possible importance of breast cancer risk. Methods: Among 204 healthy women, aged 25-35 years who participated in the Norwegian EBBA-I study, 17β-estradiol concentrations were measured in daily saliva samples throughout one entire menstrual cycle using radioimmunoassay (RIA). Attained height (cm) was measured, and serum concentrations of insulin were determined in fasting blood samples. The associations between adult height, insulin and 17β-estradiol levels throughout a menstrual cycle were studied using multivariate linear regression analyses and linear mixed models for repeated measures. Adjustments for potential confounding factors were performed. Results: A 37.2 % increase in 17β-estradiol levels was observed during the entire menstrual cycle among women with an adult height ≥170 cm (upper tertile) and insulin levels ≥ 90 pmol/L (upper tertile) compared to women with the same attained adult height, and insulin levels < 90pmol/L. The association was even more pronounced when we looked into those women with attained adult height ≥170 cm (upper tertile) and serum insulin ≥ 101 pmol/L (upper quartile) (Fig. 1). Adjustments for potential confounding factors were performed. Conclusion: Our findings support that premenopausal levels of 17β-estradiol vary in response to adult height and insulin levels, suggesting that women who become taller are put at risk for higher estradiol levels throughout the entire menstrual cycle when their insulin levels rise, of possible importance for breast cancer risk. en
dc.description.sponsorship Anthropology en
dc.description.sponsorship Human Evolutionary Biology
dc.language.iso en_US en
dc.publisher American Association for Cancer Research en
dc.relation.isversionof http://dx.doi.org/10.1158/0008-5472.SABCS-4078 en
dash.license OAP
dc.title 17β-Estradiol Levels During An Entire Menstrual Cycle In Response To Adult Stature and Insulin, Of Possible Importance For Breast Cancer Risk: The EBBA-I study. en
dc.relation.journal Cancer Research en
dash.depositing.author Ellison, Peter

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  • FAS Scholarly Articles [6948]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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