Voltage-Driven DNA Translocations through a Nanopore
| Title: | Voltage-Driven DNA Translocations through a Nanopore |
| Author: |
Branton, Daniel; Nivon, Lucas; Meller, Amit
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Meller, Amit, Lucas Nivon, and Daniel Branton. 2001. Voltage-driven DNA translocations through a nanopore. Physical Review Letters 86(15): 3435-3438. |
| Full Text & Related Files: |
VoltageDrivenDNA.pdf (194.5Kb; PDF) 
|
| Abstract: | We measure current blockade and time distributions for single-stranded DNA polymers during voltage-driven translocations through a single α-hemolysin pore. We use these data to determine the velocity of the polymers in the pore. Our measurements imply that, while polymers longer than the pore are translocated at a constant speed, the velocity of shorter polymers increases with decreasing length. This velocity is nonlinear with the applied field. Based on this data, we estimate the effective diffusion coefficient and the energy penalty for extending a molecule into the pore. |
| Published Version: | http://dx.doi.org/10.1103/PhysRevLett.86.3435 |
| Other Sources: | http://www.mcb.harvard.edu/branton/MellerEtAl2001.pdf |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:3109361 |
This item appears in the following Collection(s)
-
FAS Scholarly Articles [5171]
Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
Contact administrator regarding this item (to report mistakes or request changes)
