Brain Volume Decline in Aging
| Title: | Brain Volume Decline in Aging |
| Author: |
Morris, John C.; Fotenos, Anthony F.; Mintun, Mark A.; Snyder, Abraham Z.; Buckner, Randy
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Fotenos, Anthony F., Mark A. Mintun, Abraham Z. Snyder, John C. Morris, and Randy L. Buckner. 2008. Brain volume decline in aging. Archives of Neurology 65(1): 113-120. |
| Access Status: | At the direction of the depositing author this work is not currently accessible through DASH. |
| Full Text & Related Files: |
Buckner_BrainVolumeDecline.pdf (184.5Kb; PDF) 
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| Abstract: | Objectives: To assess the relation between socioeconomic status (SES) and structural brain change in nondemented older adults and to ascertain the potential role of preclinical Alzheimer disease (AD). Design: Cross-sectional and longitudinal observation. Setting: Alzheimer's Disease Research Center, St Louis, Missouri. Participants: Volunteer sample of 362 nondemented adults aged 18 to 93 years. The main cohort of 100 was evaluated for dementia and SES; a Clinical Dementia Rating (CDR) of 0 (no dementia) and middle, high-middle, or high SES was required for eligibility. All 362 received magnetic resonance imaging; of the main 100, 91 received follow-up clinical assessment, and 33 received follow-up magnetic resonance imaging over at least a 3-year interval. A separate sample of 58 CDR 0 participants (aged 47 to 86 years) took part in amyloid imaging with Pittsburgh Compound B (PiB) labeled with radioactive carbon (C-11). Main Outcome Measures: Whole-brain volume adjusted for head size (aWBV) and change per year. Results: aWBV declined by 0:22% per year between the ages of 20 and 80 years with accelerated decline in advanced aging. Controlling for effects of age and sex in older adults (> 65 years) with CDR 0, higher SES was associated with smaller aWBV (3.8% difference spanning the sample range from middle to high privilege, P <.01) and more rapid volume loss (0.39% per year to 0.68% per year from middle to high privilege, P <.05). aWBV was reduced by 2.5% in individuals positive for PiB binding (n=9) as compared with individuals negative for PiB binding (n=49, P < .05), supporting an influence of undetected preclinical AD. Follow-up clinical data revealed that brain volume reduction associated with SES was greater in those who later developed very mild dementia (preclinical CDR 0 group, n=19) compared with those who remained nondemented (stable CDR 0 group, n=64; group X SES interaction, P <.05). Conclusions: Privileged nondemented older adults harbor more preclinical brain atrophy, consistent with their having greater reserve against the expression of AD. |
| Published Version: | http://dx.doi.org/10.1001/archneurol.2007.27 |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:3203279 |
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