Viral Membrane Fusion
| Title: | Viral Membrane Fusion |
| Author: | Harrison, Stephen |
| Citation: | Harrison, Stephen C. 2008. Viral membrane fusion. Nature Structural and Molecular Biology 15, no. 7: 690-698. |
| Full Text & Related Files: |
Harrison_ViralMembraneFusion.pdf (1.105Mb; PDF) 
|
| Abstract: | Infection by viruses having lipid-bilayer envelopes proceeds through fusion of the viral membrane with a membrane of the target cell. Viral ‘fusion proteins’ facilitate this process. They vary greatly in structure, but all seem to have a common mechanism of action, in which a ligand-triggered, largescale conformational change in the fusion protein is coupled to apposition and merger of the two bilayers. We describe three examples—the influenza virus hemagglutinin, the flavivirus E protein and the vesicular stomatitis virus G protein—in some detail, to illustrate the ways in which different structures have evolved to implement this common mechanism. Fusion inhibitors can be effective antiviral agents. |
| Published Version: | http://dx.doi.org/10.1038/nsmb.1456 |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:3710801 |
This item appears in the following Collection(s)
-
FAS Scholarly Articles [5137]
Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
Contact administrator regarding this item (to report mistakes or request changes)
