Adult Height, Insulin Levels and 17β-Estradiol in Young Women

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Adult Height, Insulin Levels and 17β-Estradiol in Young Women

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dc.contributor.author Finstad, Sissi Espetvedt
dc.contributor.author Emaus, Aina
dc.contributor.author Tretli, Steinar
dc.contributor.author Jasienska, Grazyna
dc.contributor.author Ellison, Peter T.
dc.contributor.author Furberg, Anne-Sofie
dc.contributor.author Wist, Erik A.
dc.contributor.author Thune, Inger
dc.date.accessioned 2010-06-24T19:56:48Z
dc.date.issued 2009
dc.identifier.citation Finstad, Sissi Espetvedt, Aina Emaus, Steinar Tretli, Grazyna Jasienska, Peter T. Ellison, Anne-Sofie Furberg, Erik A. Wist, and Inger Thune. 2009. Adult height, insulin levels, and 17beta-estadiol in young women. Cancer Epidemiology Biomarkers and Prevention 18(5): 1477-1483. en_US
dc.identifier.issn 1055-9965 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4262996
dc.description.abstract Background: Adult height and insulin levels have independently been associated with breast cancer risk. However, little is known about whether these factors influence estradiol levels. Thus, we hypothesize that adult height in combination with insulin levels may influence premenopausal 17β-estradiol throughout the entire menstrual cycle of possible importance of breast cancer risk. Methods: Among 204 healthy women, aged 25-35 years who participated in the Norwegian EBBA I study, birth weight and age at menarche were assessed by questionnaire, personal health record and interview. 17β-estradiol concentrations were estimated by daily saliva samples throughout one entire menstrual cycle using radioimmunoassay (RIA). Measures of height (cm) were taken as well as waist circumference (cm), body mass index (BMI kg/m2) and total fat percentage (DEXA % fat). Fasting blood samples were drawn, and serum concentrations of insulin were determined. Results: The women reported a mean height of 166.5 cm, birth weight of 3389 g and age at menarche 13.1 years. Mean BMI was 24.4 kg/m2, mean waist circumference 79.5 cm and mean total fat percentage 34.1%. Women with an adult height of more than 170 cm and insulin levels higher than 90 pmol/L experienced on average an 37.2 % increase in 17β- estradiol during an entire menstrual cycle compared to those with the same height, and insulin levels below 90 pmol/L. Moreover, this was also observed throughout the entire menstrual cycle. Conclusion: Our findings support that premenopausal levels of 17β-estradiol vary in response to adult height and insulin levels, suggesting that women who become taller are put at risk for higher estradiol levels when their insulin levels rise of possible importance for breast cancer risk. en_US
dc.description.sponsorship Anthropology en_US
dc.language.iso en_US en_US
dc.publisher American Association for Cancer Research en_US
dc.relation.isversionof doi:10.1158/1055-9965.EPI-08-0972 en_US
dash.license LAA
dc.subject adult height en_US
dc.subject insulin levels en_US
dc.subject 17 β-estradiol en_US
dc.subject Norway en_US
dc.title Adult Height, Insulin Levels and 17β-Estradiol in Young Women en_US
dc.type Journal Article en_US
dc.description.version Accepted Manuscript en_US
dc.relation.journal Cancer Epidemiology Biomarkers and Prevention en_US
dash.depositing.author Ellison, Peter T.
dash.waiver 2010-06-24
dc.date.available 2010-06-24T19:56:48Z

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  • FAS Scholarly Articles [7470]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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