The Cost of Gene Expression Underlies a Fitness Trade-Off in Yeast

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The Cost of Gene Expression Underlies a Fitness Trade-Off in Yeast

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Title: The Cost of Gene Expression Underlies a Fitness Trade-Off in Yeast
Author: Lang, Gregory I.; Murray, Andrew W.; Botstein, David

Note: Order does not necessarily reflect citation order of authors.

Citation: Lang, Gregory I., Andrew W. Murray, and David Botstein. 2009. The cost of gene expression underlies a fitness trade-off in yeast. Proceedings of the National Academy of Sciences 106(14): 5755-5760.
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Abstract: Natural selection optimizes an organism's genotype within the context of its environment. Adaptations to one environment can decrease fitness in another, revealing evolutionary trade-offs. Here, we show that the cost of gene expression underlies a trade-off between growth rate and mating efficiency in the yeast Saccharomyces cerevisiae. During asexual growth, mutations that eliminate the ability to mate provide an ≈2% per-generation growth-rate advantage. Some strains, including most laboratory strains, carry an allele of GPA1 (an upstream component of the mating pathway) that increases mating efficiency by ≈30% per round of mating at the cost of an ≈1% per-generation growth-rate disadvantage. In addition to demonstrating a trade-off between growth rate and mating efficiency, our results illustrate differences in the selective pressures defining fitness in the laboratory versus the natural environment and show that selection, acting on the cost of gene expression, can optimize expression levels and promote gene loss.
Published Version: doi:10.1073/pnas.0901620106
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4314513

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  • FAS Scholarly Articles [6898]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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