Fitness Variation Due To Sexual Antagonism and Linkage Disequilibrium

Fitness Variation Due To Sexual Antagonism and Linkage Disequilibrium

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Fitness Variation Due To Sexual Antagonism and Linkage Disequilibrium

dc.contributor.author	Patten, Manus Michael
dc.contributor.author	Haig, David Addison
dc.contributor.author	Ubeda, Francisco
dc.date.accessioned	2010-07-29T17:24:36Z
dc.date.issued	2010
dc.identifier.citation	Patten, Manus M., David Haig, and Francisco Ubeda. Forthcoming. Fitness variation due to sexual antagonism and linkage disequilibrium. Evolution: International Journal of Organic Evolution 64.	en_US
dc.identifier.issn	1558-5646	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4321894
dc.description.abstract	Extensive fitness variation for sexually antagonistic characters has been detected in nature. However, current population genetic theory suggests that sexual antagonism is unlikely to play a major role in the maintenance of variation. We present a two-locus model of sexual antagonism that is capable of explaining greater fitness variance at equilibrium than previous single-locus models. The second genetic locus provides additional fitness variance in two complementary ways. First, linked loci can maintain gene variants that are lost in single-locus models of evolution, expanding the opportunity for polymorphism. Second, linkage disequilibrium results between any two sexually antagonistic genes, producing an excess of high and low fitness haplotypes. Our results uncover a unique contribution of conflicting selection pressures to the maintenance of variation, which simpler models that neglect genetic architecture overlook.	en_US
dc.description.sponsorship	Organismic and Evolutionary Biology	en_US
dc.language.iso	en_US	en_US
dc.publisher	Wiley-Blackwell	en_US
dc.relation.isversionof	http://www.wiley.com/bw/journal.asp?ref=0014-3820	en_US
dash.license	LAA
dc.title	Fitness Variation Due To Sexual Antagonism and Linkage Disequilibrium	en_US
dc.type	Journal Article	en_US
dc.description.version	Accepted Manuscript	en_US
dc.relation.journal	Evolution: International Journal of Organic Evolution	en_US
dash.depositing.author	Haig, David Addison
dash.waiver	2010-07-27
dc.date.available	2010-07-29T17:24:36Z