Divide and Conquer: High Resolution Structural Information on TRP Channel Fragments

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Divide and Conquer: High Resolution Structural Information on TRP Channel Fragments

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Title: Divide and Conquer: High Resolution Structural Information on TRP Channel Fragments
Author: Gaudet, Rachelle
Citation: Gaudet, Rachelle. 2009. Divide and conquer: High resolution structural information on TRP channel fragments. The Journal of General Physiology 133(3): 231-237.
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Abstract: Understanding how proteins facilitate signaling and substrate transport across biological membranes is an important frontier of structural biology. Membrane proteins are the doors and windows of cells: many membrane proteins are gates of entry into or exit from cells or cellular compartments, and others allow cells to sense their environment. One important multifunctional family of membrane proteins is the transient receptor potential (TRP) family of ion channels. TRP channels have recently been the subject of multiple structural analyses, both low resolution electron microscopy studies (reviewed by Moiseenkova-Bell and Wensel in this issue [p. 239]) and the divide and conquer approach of determining high resolution crystal structures of channel fragments, reviewed here.
Published Version: doi:10.1085/jgp.200810137
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4340149

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  • FAS Scholarly Articles [6885]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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