The Association between Hypertension and Depression and Anxiety Disorders: Results from a Nationally-Representative Sample of South African Adults

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The Association between Hypertension and Depression and Anxiety Disorders: Results from a Nationally-Representative Sample of South African Adults

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dc.contributor.author Grimsrud, Anna
dc.contributor.author Seedat, Soraya
dc.contributor.author Myer, Landon
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Stein, Dan J.
dc.contributor.author Williams, David
dc.date.accessioned 2010-09-29T20:31:36Z
dc.date.issued 2009
dc.identifier.citation Grimsrud, Anna, Dan J.Stein, Soraya Seedat, David Williams, Landon Myer, and J. Jaime Miranda. 2009. The association between hypertension and depression and anxiety disorders: Results from a nationally-representative sample of South African adults. PLoS ONE 4(5): e5552. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4453999
dc.description.abstract Objective Growing evidence suggests high levels of comorbidity between hypertension and mental illness but there are few data from low- and middle-income countries. We examined the association between hypertension and depression and anxiety in South Africa.Methods Data come from a nationally-representative survey of adults (n = 4351). The Composite International Diagnostic Interview was used to measure DSM-IV mental disorders during the previous 12-months. The relationships between self-reported hypertension and anxiety disorders, depressive disorders and comorbid anxiety-depression were assessed after adjustment for participant characteristics including experience of trauma and other chronic physical conditions.Results Overall 16.7% reported a previous medical diagnosis of hypertension, and 8.1% and 4.9% were found to have a 12-month anxiety or depressive disorder, respectively. In adjusted analyses, hypertension diagnosis was associated with 12-month anxiety disorders [Odds ratio (OR) = 1.55, 95% Confidence interval (CI) = 1.10–2.18] but not 12-month depressive disorders or 12-month comorbid anxiety-depression. Hypertension in the absence of other chronic physical conditions was not associated with any of the 12-month mental health outcomes (p-values all <0.05), while being diagnosed with both hypertension and another chronic physical condition were associated with 12-month anxiety disorders (OR = 2.25, 95% CI = 1.46–3.45), but not 12-month depressive disorders or comorbid anxiety-depression.Conclusions These are the first population-based estimates to demonstrate an association between hypertension and mental disorders in sub-Saharan Africa. Further investigation is needed into role of traumatic life events in the aetiology of hypertension as well as the temporality of the association between hypertension and mental disorders. en_US
dc.description.sponsorship African and African American Studies en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0005552 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678252/pdf/ en_US
dash.license OAP
dc.subject mental health en_US
dc.subject cardiovascular disorders/hypertension en_US
dc.subject mental health/anxiety disorders en_US
dc.subject mental health/mood disorders en_US
dc.title The Association between Hypertension and Depression and Anxiety Disorders: Results from a Nationally-Representative Sample of South African Adults en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Williams, David
dc.date.available 2010-09-29T20:31:36Z

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  • FAS Scholarly Articles [5138]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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