dc.contributor.author | Grimsrud, Anna | |
dc.contributor.author | Stein, Dan J. | |
dc.contributor.author | Seedat, Soraya | |
dc.contributor.author | Williams, David | |
dc.contributor.author | Myer, Landon | |
dc.contributor.author | Miranda, J. Jaime | |
dc.date.accessioned | 2010-09-29T20:31:36Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Grimsrud, Anna, Dan J.Stein, Soraya Seedat, David Williams, Landon Myer, and J. Jaime Miranda. 2009. The association between hypertension and depression and anxiety disorders: Results from a nationally-representative sample of South African adults. PLoS ONE 4(5): e5552. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4453999 | |
dc.description.abstract | Objective Growing evidence suggests high levels of comorbidity between hypertension and mental illness but there are few data from low- and middle-income countries. We examined the association between hypertension and depression and anxiety in South Africa.Methods Data come from a nationally-representative survey of adults (n = 4351). The Composite International Diagnostic Interview was used to measure DSM-IV mental disorders during the previous 12-months. The relationships between self-reported hypertension and anxiety disorders, depressive disorders and comorbid anxiety-depression were assessed after adjustment for participant characteristics including experience of trauma and other chronic physical conditions.Results Overall 16.7% reported a previous medical diagnosis of hypertension, and 8.1% and 4.9% were found to have a 12-month anxiety or depressive disorder, respectively. In adjusted analyses, hypertension diagnosis was associated with 12-month anxiety disorders [Odds ratio (OR) = 1.55, 95% Confidence interval (CI) = 1.10–2.18] but not 12-month depressive disorders or 12-month comorbid anxiety-depression. Hypertension in the absence of other chronic physical conditions was not associated with any of the 12-month mental health outcomes (p-values all <0.05), while being diagnosed with both hypertension and another chronic physical condition were associated with 12-month anxiety disorders (OR = 2.25, 95% CI = 1.46–3.45), but not 12-month depressive disorders or comorbid anxiety-depression.Conclusions These are the first population-based estimates to demonstrate an association between hypertension and mental disorders in sub-Saharan Africa. Further investigation is needed into role of traumatic life events in the aetiology of hypertension as well as the temporality of the association between hypertension and mental disorders. | en_US |
dc.description.sponsorship | African and African American Studies | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi:10.1371/journal.pone.0005552 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678252/pdf/ | en_US |
dash.license | OAP | |
dc.subject | mental health | en_US |
dc.subject | cardiovascular disorders/hypertension | en_US |
dc.subject | mental health/anxiety disorders | en_US |
dc.subject | mental health/mood disorders | en_US |
dc.title | The Association between Hypertension and Depression and Anxiety Disorders: Results from a Nationally-Representative Sample of South African Adults | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS ONE | en_US |
dash.depositing.author | Williams, David | |
dc.date.available | 2010-09-29T20:31:36Z | |
dc.identifier.doi | 10.1371/journal.pone.0005552 | * |
dash.contributor.affiliated | Williams, David | |