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Title:	Dynamic Remodeling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex
Author:	Huang, Hayden; Feng, Guoping; So, Peter T; Nedivi, Elly; Stevens, Charles F.; Lee, Wei-Chung A; Sanes, Joshua R.; Brown, Emery Neal Note: Order does not necessarily reflect citation order of authors.
Citation:	Lee, Wei-Chung Allen, Hayden Huang, Guoping Feng, Joshua R. Sanes, Emery N. Brown, Peter T. So, Elly Nedivi, and Charles F. Stevens. 2006. Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex. PLoS Biology 4(2): e29.
Full Text & Related Files:	1318477.pdf (997.2Kb; PDF)
Abstract:	Despite decades of evidence for functional plasticity in the adult brain, the role of structural plasticity in its manifestation remains unclear. To examine the extent of neuronal remodeling that occurs in the brain on a day-to-day basis, we used a multiphoton-based microscopy system for chronic in vivo imaging and reconstruction of entire neurons in the superficial layers of the rodent cerebral cortex. Here we show the first unambiguous evidence (to our knowledge) of dendrite growth and remodeling in adult neurons. Over a period of months, neurons could be seen extending and retracting existing branches, and in rare cases adding new branch tips. Neurons exhibiting dynamic arbor rearrangements were GABA-positive non-pyramidal interneurons, while pyramidal cells remained stable. These results are consistent with the idea that dendritic structural remodeling is a substrate for adult plasticity and they suggest that circuit rearrangement in the adult cortex is restricted by cell type–specific rules.
Published Version:	doi:10.1371/journal.pbio.0040029
Other Sources:	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1318477/pdf/
Terms of Use:	This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page:	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4454162

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  Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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