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dc.contributor.authorArtyomov, Maxim N.
dc.contributor.authorMeissner, Alexander
dc.contributor.authorChakraborty, Arup K.
dc.date.accessioned2010-09-30T14:44:22Z
dc.date.issued2010
dc.identifier.citationArtyomov, Maxim N., Alexander Meissner, and Arup K. Chakraborty. 2010. A Model for Genetic and Epigenetic Regulatory Networks Identifies Rare Pathways for Transcription Factor Induced Pluripotency. PLoS Computational Biology 6(5): e1000785.en_US
dc.identifier.issn1553-734Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4454183
dc.description.abstractWith relatively low efficiency, differentiated cells can be reprogrammed to a pluripotent state by ectopic expression of a few transcription factors. An understanding of the mechanisms that underlie data emerging from such experiments can help design optimal strategies for creating pluripotent cells for patient-specific regenerative medicine. We have developed a computational model for the architecture of the epigenetic and genetic regulatory networks which describes transformations resulting from expression of reprogramming factors. Importantly, our studies identify the rare temporal pathways that result in induced pluripotent cells. Further experimental tests of predictions emerging from our model should lead to fundamental advances in our understanding of how cellular identity is maintained and transformed.en_US
dc.description.sponsorshipStem Cell and Regenerative Biologyen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pcbi.1000785en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869311/pdf/en_US
dash.licenseOAP
dc.subjectbiophysicsen_US
dc.subjecttheory and simulationen_US
dc.titleA Model for Genetic and Epigenetic Regulatory Networks Identifies Rare Pathways for Transcription Factor Induced Pluripotencyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Computational Biologyen_US
dash.depositing.authorMeissner, Alexander
dc.date.available2010-09-30T14:44:22Z
dc.identifier.doi10.1371/journal.pcbi.1000785*
dash.contributor.affiliatedMeissner, Alexander


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