Browsing Harvard Medical School by Title

Now showing items 10008-10027 of 18428

    • LMKB/MARF1 Localizes to mRNA Processing Bodies, Interacts with Ge-1, and Regulates IFI44L Gene Expression 

      Bloch, Donald B.; Li, Pingcheng; Bloch, Emily G.; Berenson, Daniel F.; Galdos, Rita L.; Arora, Pankaj; Malhotra, Rajeev; Wu, Connie; Yang, Weihong (Public Library of Science, 2014)
      The mRNA processing body (P-body) is a cellular structure that regulates the stability of cytoplasmic mRNA. MARF1 is a murine oocyte RNA-binding protein that is associated with maintenance of mRNA homeostasis and genomic ...

    • lncRNA CRNDE204 regulates erythropoiesis and myelopoiesis by binding to PUS1 

      Hu, Jingwen (2021-07-19)
      Hematopoiesis is a crucial process that produces all cells within the hematopoietic system. Mutations in genes that disrupt normal hematopoiesis can cause bone marrow failure disorders ranging from myelodysplastic syndromes ...

    • The lncRNA DEANR1 Facilitates Human Endoderm Differentiation by Activating FOXA2 Expression 

      Jiang, Wei; Liu, Yuting; Liu, Rui; Zhang, Kun; Zhang, Yi (Elsevier BV, 2015)
      Long non-coding RNAs (lncRNAs) regulate diverse biological processes, including cell lineage specification. Here, we report transcriptome profiling of human endoderm and pancreatic cell lineages using purified cell ...

    • Lobar Pneumonia Treated by Musgrave Park Physicians 

      Hedley-Whyte, John; Milamed, Debra (The Ulster Medical Society, 2009)
      In the decade 1935-45 the treatment of lobar pneumonia in the developed and warring world underwent a series of evolutions—anti-sera, specific anti-sera, refinement of sulpha drugs, sulpha and anti-sera, the introduction ...

    • Local Application of Leptin Antagonist Attenuates Angiotensin II–Induced Ascending Aortic Aneurysm and Cardiac Remodeling 

      Ben‐Zvi, Danny; Savion, Naphtali; Kolodgie, Frank; Simon, Amos; Fisch, Sudeshna; Schäfer, Katrin; Bachner‐Hinenzon, Noa; Cao, Xin; Gertler, Arieh; Solomon, Gili; Kachel, Erez; Raanani, Ehud; Lavee, Jacob; Kotev Emeth, Shlomo; Virmani, Renu; Schoen, Frederick J.; Schneiderman, Jacob (John Wiley and Sons Inc., 2016)
      Background: Ascending thoracic aortic aneurysm (ATAA) is driven by angiotensin II (AngII) and contributes to the development of left ventricular (LV) remodeling through aortoventricular coupling. We previously showed that ...

    • Local Area Cartilage Segmentation: A Semiautomated Novel Method of Measuring Cartilage Loss in Knee Osteoarthritis 

      Duryea, Jeffrey; Iranpour-Boroujeni, Tannaz; Collins, Jamie; Vanwynngaarden, Case; Guermazi, Ali; Katz, Jeffrey; Losina, Elena; Russell, Ruby; Ratzlaff, Charles (Wiley, 2014-10)
      Objective To assess the responsiveness and reader time of a novel semiautomated tool to detect knee cartilage loss over 2 years in subjects with knee osteoarthritis. Methods A total of 122 subjects from the Osteoarthritis ...

    • Local Clustering of Transferrin Receptors Promotes Clathrin-Coated Pit Initiation 

      Liu, Allen P.; Aguet, Francois; Danuser, Gaudenz; Schmid, Sandra L. (Rockefeller University Press, 2010)
      Clathrin-mediated endocytosis (CME) is the major pathway for concentrative uptake of receptors and receptor–ligand complexes (cargo). Although constitutively internalized cargos are known to accumulate into maturing ...

    • Local Concepts of Anemia-Related Illnesses and Public Health Implications in the Taabo Health Demographic Surveillance System, Côte d’Ivoire 

      Kouadio, M’Bra KD; Righetti, Aurélie A; Abé, Noël N; Wegmüller, Rita; Weiss, Mitchell; N’Goran, Eliézer K; Utzinger, Jürg (Springer Science and Business Media LLC, 2013-05-06)
      Background A 14-month prospective longitudinal study conducted in the Taabo health demographic surveillance system (HDSS), south-central Côte d’Ivoire, revealed high prevalence of anemia in different population groups in ...

    • Local cortical dynamics of burst suppression in the anaesthetized brain 

      Lewis, Laura D.; Ching, ShiNung; Weiner, Veronica S.; Peterfreund, Robert A.; Eskandar, Emad N.; Cash, Sydney S.; Brown, Emery N.; Purdon, Patrick L. (Oxford University Press, 2013)
      Burst suppression is an electroencephalogram pattern that consists of a quasi-periodic alternation between isoelectric ‘suppressions’ lasting seconds or minutes, and high-voltage ‘bursts’. It is characteristic of a profoundly ...

    • Local delivery of fluorescent dye for fiber-optics confocal microscopy of the living heart 

      Huang, Chao; Kaza, Aditya K.; Hitchcock, Robert W.; Sachse, Frank B. (Frontiers Media S.A., 2014)
      Fiber-optics confocal microscopy (FCM) is an emerging imaging technology with various applications in basic research and clinical diagnosis. FCM allows for real-time in situ microscopy of tissue at sub-cellular scale. ...

    • Local field potentials primarily reflect inhibitory neuron activity in human and monkey cortex 

      Teleńczuk, Bartosz; Dehghani, Nima; Le Van Quyen, Michel; Cash, Sydney S.; Halgren, Eric; Hatsopoulos, Nicholas G.; Destexhe, Alain (Nature Publishing Group, 2017)
      The local field potential (LFP) is generated by large populations of neurons, but unitary contribution of spiking neurons to LFP is not well characterised. We investigated this contribution in multi-electrode array recordings ...

    • Local microRNA delivery targets Palladin and prevents metastatic breast cancer 

      Gilam, Avital; Conde, João; Weissglas-Volkov, Daphna; Oliva, Nuria; Friedman, Eitan; Artzi, Natalie; Shomron, Noam (Nature Publishing Group, 2016)
      Metastasis is the primary cause for mortality in breast cancer. MicroRNAs, gene expression master regulators, constitute an attractive candidate to control metastasis. Here we show that breast cancer metastasis can be ...

    • Local Perceptions of Cholera and Anticipated Vaccine Acceptance in Katanga Province, Democratic Republic of Congo 

      Merten, Sonja; Schaetti, Christian; Manianga, Cele; Lapika, Bruno; Chaignat, Claire-Lise; Hutubessy, Raymond; Weiss, Mitchell (Springer Science and Business Media LLC, 2013-01-22)
      Background In regions where access to clean water and the provision of a sanitary infrastructure has not been sustainable, cholera continues to pose an important public health burden. Although oral cholera vaccines (OCV) ...

    • Local production of medical technologies and its effect on access in low and middle income countries: a systematic review of the literature 

      Kaplan, Warren Allan; Ritz, Lindsay Sarah; Vitello, Marie (Dr. Zaheer-Ud-Din Babar, 2011)
      Objectives: The objective of this study was to assess the existing theoretical and empirical literature examining the link between "local production" of pharmaceuticals and medical devices and increased local access to ...

    • Local proliferation dominates lesional macrophage accumulation in atherosclerosis 

      Robbins, Clinton S.; Hilgendorf, Ingo; Weber, Georg F.; Theurl, Igor; Iwamoto, Yoshiko; Figueiredo, Jose-Luiz; Gorbatov, Rostic; Sukhova, Galina K.; Gerhardt, Louisa M.S.; Smyth, David; Zavitz, Caleb C. J.; Shikatani, Eric A.; Parsons, Michael; van Rooijen, Nico; Lin, Herbert Y.; Husain, Mansoor; Libby, Peter; Nahrendorf, Matthias; Weissleder, Ralph; Swirski, Filip K. (2013)
      During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall1,2. The observation that circulating monocytes give rise to lesional macrophages3–9 has ...

    • Local regulation of gene expression by lncRNA promoters, transcription and splicing 

      Engreitz, Jesse M.; Haines, Jenna E.; Perez, Elizabeth M.; Munson, Glen; Chen, Jenny; Kane, Michael; McDonel, Patrick E.; Guttman, Mitchell; Lander, Eric Steven (Springer Nature, 2016)
      Mammalian genomes are pervasively transcribed1, to produce thousands of long non-coding RNAs (lncRNAs). A few of these lncRNAs have been shown to recruit regulatory complexes through RNA–protein interactions to influence ...

    • Local Replication of Simian Immunodeficiency Virus in the Breast Milk Compartment of Chronically-infected, Lactating Rhesus Monkeys 

      Permar, Sallie Robey; Kang, Helen H; Wilks, Andrew B; Mach, Linh V; Carville, Angela A L; Mansfield, Keith G.; Learn, Gerald H; Hahn, Beatrice H; Letvin, Norman Lee (BioMed Central, 2010)
      Breast milk transmission remains a major mode of infant HIV acquisition, yet anatomic and immunologic forces shaping virus quasispecies in milk are not well characterized. In this study, phylogenic analysis of envelope ...

    • Local Treatment With Alpha-Melanocyte Stimulating Hormone Reduces Corneal Allorejection 

      Hamrah, Pedram; Haskova, Zdenka; Taylor, Andrew W.; Zhang, Qiang; Ksander, Bruce R.; Dana, Reza (Ovid Technologies (Wolters Kluwer Health), 2009)
      Background Corneal grafting is by far the most common form of transplantation. Many grafts suffer from immune rejection and current therapies are associated with many side effects, requiring more effective and safe ...

    • Local white matter geometry from diffusion tensor gradients 

      Savadjiev, Peter; Kindlmann, Gordon L.; Bouix, Sylvain; Shenton, Martha Elizabeth; Westin, Carl-Fredrik (Elsevier BV, 2010)
      We introduce a mathematical framework for computing geometrical properties of white matter fibres directly from diffusion tensor fields. The key idea is to isolate the portion of the gradient of the tensor field corresponding ...

    • Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution 

      Cabili, Moran N; Dunagin, Margaret C; McClanahan, Patrick D; Biaesch, Andrew; Padovan-Merhar, Olivia; Regev, Aviv; Rinn, John L; Raj, Arjun (BioMed Central, 2015)
      Background: Long non-coding RNAs (lncRNAs) have been implicated in diverse biological processes. In contrast to extensive genomic annotation of lncRNA transcripts, far fewer have been characterized for subcellular localization ...