Browsing Harvard Medical School by Title
Now showing items 10016-10035 of 18428
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Local cortical dynamics of burst suppression in the anaesthetized brain
(Oxford University Press, 2013)Burst suppression is an electroencephalogram pattern that consists of a quasi-periodic alternation between isoelectric ‘suppressions’ lasting seconds or minutes, and high-voltage ‘bursts’. It is characteristic of a profoundly ... -
Local delivery of fluorescent dye for fiber-optics confocal microscopy of the living heart
(Frontiers Media S.A., 2014)Fiber-optics confocal microscopy (FCM) is an emerging imaging technology with various applications in basic research and clinical diagnosis. FCM allows for real-time in situ microscopy of tissue at sub-cellular scale. ... -
Local field potentials primarily reflect inhibitory neuron activity in human and monkey cortex
(Nature Publishing Group, 2017)The local field potential (LFP) is generated by large populations of neurons, but unitary contribution of spiking neurons to LFP is not well characterised. We investigated this contribution in multi-electrode array recordings ... -
Local microRNA delivery targets Palladin and prevents metastatic breast cancer
(Nature Publishing Group, 2016)Metastasis is the primary cause for mortality in breast cancer. MicroRNAs, gene expression master regulators, constitute an attractive candidate to control metastasis. Here we show that breast cancer metastasis can be ... -
Local Perceptions of Cholera and Anticipated Vaccine Acceptance in Katanga Province, Democratic Republic of Congo
(Springer Science and Business Media LLC, 2013-01-22)Background In regions where access to clean water and the provision of a sanitary infrastructure has not been sustainable, cholera continues to pose an important public health burden. Although oral cholera vaccines (OCV) ... -
Local production of medical technologies and its effect on access in low and middle income countries: a systematic review of the literature
(Dr. Zaheer-Ud-Din Babar, 2011)Objectives: The objective of this study was to assess the existing theoretical and empirical literature examining the link between "local production" of pharmaceuticals and medical devices and increased local access to ... -
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
(2013)During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall1,2. The observation that circulating monocytes give rise to lesional macrophages3–9 has ... -
Local regulation of gene expression by lncRNA promoters, transcription and splicing
(Springer Nature, 2016)Mammalian genomes are pervasively transcribed1, to produce thousands of long non-coding RNAs (lncRNAs). A few of these lncRNAs have been shown to recruit regulatory complexes through RNA–protein interactions to influence ... -
Local Replication of Simian Immunodeficiency Virus in the Breast Milk Compartment of Chronically-infected, Lactating Rhesus Monkeys
(BioMed Central, 2010)Breast milk transmission remains a major mode of infant HIV acquisition, yet anatomic and immunologic forces shaping virus quasispecies in milk are not well characterized. In this study, phylogenic analysis of envelope ... -
Local Treatment With Alpha-Melanocyte Stimulating Hormone Reduces Corneal Allorejection
(Ovid Technologies (Wolters Kluwer Health), 2009)Background Corneal grafting is by far the most common form of transplantation. Many grafts suffer from immune rejection and current therapies are associated with many side effects, requiring more effective and safe ... -
Local white matter geometry from diffusion tensor gradients
(Elsevier BV, 2010)We introduce a mathematical framework for computing geometrical properties of white matter fibres directly from diffusion tensor fields. The key idea is to isolate the portion of the gradient of the tensor field corresponding ... -
Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution
(BioMed Central, 2015)Background: Long non-coding RNAs (lncRNAs) have been implicated in diverse biological processes. In contrast to extensive genomic annotation of lncRNA transcripts, far fewer have been characterized for subcellular localization ... -
Localization and Network of Coma-Causing Brainstem Lesions: Evidence for a Human Consciousness Network
(2016-05-17)Focal brainstem lesions can disrupt arousal and cause coma, yet the exact location of the brainstem region critical to arousal and its associated network are unknown. First, we compare brainstem lesions between 12 patients ... -
Localization of Collagen XVIII and the Endostatin Portion of Collagen XVIII in Aged Human Control Eyes and Eyes with Age-Related Macular Degeneration
(Association for Research in Vision and Ophthalmology (ARVO), 2004-05-01)purpose. Endostatin, a C-terminal fragment of collagen XVIII (coll XVIII) formed by proteolysis, specifically inhibits endothelial cell migration and proliferation in vitro and potently inhibits angiogenesis and tumor ... -
Localization of Eosinophilic Esophagitis from H&E Stained Images Using Multispectral Imaging
(BioMed Central, 2011)This study is an initial investigation on the capability of multispectral imaging to capture subtle spectral information that would enable the automatic delineation between the eosinophilic esophagitis and other eosin ... -
Localization of Mammalian Orthoreovirus Proteins to Cytoplasmic Factory-Like Structures via Nonoverlapping Regions of μNS
(American Society for Microbiology, 2010) -
Localization of the Epileptogenic Foci in Tuberous Sclerosis Complex: A Pediatric Case Report
(Frontiers Media S.A., 2014)Tuberous sclerosis complex (TSC) is a rare disorder of tissue growth and differentiation, characterized by benign hamartomas in the brain and other organs. Up to 90% of TSC patients develop epilepsy and 50% become medically ... -
Localization to the Proteasome is Sufficient for Degradation
(Elsevier BV, 2004-05-14)The majority of unstable proteins in eukaryotic cells are targeted for degradation through the ubiquitin-proteasome pathway. Substrates for degradation are recognized by the E1, E2, and E3 ubiquitin conjugation machinery ... -
Localized abnormalities in the cingulum bundle in patients with schizophrenia: A Diffusion Tensor tractography study
(Elsevier, 2014)The cingulum bundle (CB) connects gray matter structures of the limbic system and as such has been implicated in the etiology of schizophrenia. There is growing evidence to suggest that the CB is actually comprised of a ... -
Localized attacks on spatially embedded networks with dependencies
(Nature Publishing Group, 2015)Many real world complex systems such as critical infrastructure networks are embedded in space and their components may depend on one another to function. They are also susceptible to geographically localized damage caused ...