Browsing Harvard Medical School by Title
Now showing items 12-31 of 18428
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[18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography of LAPC4-CR Castration-Resistant Prostate Cancer Xenograft Model in Soft Tissue Compartments1
(Neoplasia Press, 2015)Preclinical xenograft models have contributed to advancing our understanding of the molecular basis of prostate cancer and to the development of targeted therapy. However, traditional preclinical in vivo techniques using ... -
18q Loss of Heterozygosity in Microsatellite Stable Colorectal Cancer is Correlated with CpG Island Methylator Phenotype-negative (CIMP-0) and Inversely with CIMP-low and CIMP-high
(BioMed Central, 2007)Background: The CpG island methylator phenotype (CIMP) with widespread promoter methylation is a distinct epigenetic phenotype in colorectal cancer, associated with microsatellite instability-high (MSI-high) and BRAF ... -
A 19-year-old at 37 weeks gestation with an acute acetylsalicylic acid overdose
(Oxford University Press, 2011)Acute salicylate overdose in pregnancy is potentially fatal for both the mother and fetus and presents a unique challenge in intensive care management. While suggested thresholds exist for hemodialysis in adults with toxic ... -
2-Year BMI Changes of Children Referred for Multidisciplinary Weight Management
(Hindawi Publishing Corporation, 2014)Objective. To examine body mass index (BMI) changes among pediatric multidisciplinary weight management participants and nonparticipants. Design. In this retrospective database analysis, we used multivariable mixed effect ... -
20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice
(Public Library of Science, 2010)Background Ozone, a pollutant known to induce airway hyper-responsiveness (AHR), increases morbidity and mortality in patients with obstructive airway diseases and asthma. We postulate oxidized lipids mediate in vivo ... -
2001: A Mouse Genome Odyssey
(BioMed Central, 2002)A report on the 15th International Mouse Genome Conference, Edinburgh, UK, 21-24 October 2001. -
The 2007 WHO Classification of Tumours of the Central Nervous System
(Springer-Verlag, 2007)The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, ... -
2016 WSES guidelines on acute calculous cholecystitis
(BioMed Central, 2016)Acute calculus cholecystitis is a very common disease with several area of uncertainty. The World Society of Emergency Surgery developed extensive guidelines in order to cover grey areas. The diagnostic criteria, the ... -
24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex
(Public Library of Science, 2014)Circadian rhythms modulate the biology of many human tissues, including brain tissues, and are driven by a near 24-hour transcriptional feedback loop. These rhythms are paralleled by 24-hour rhythms of large portions of ... -
24H FOLLOW-UP CT| METFORMIN PRETREATMENT: TWO REFLECTIONS FROM CLINICAL STROKE PRACTICE
(2023-05-11)Acute ischemic stroke is a serious medical emergency caused by the blockage of blood flow to the brain. With an estimated 15 million new cases each year, it is a leading cause of morbidity and mortality worldwide. The ... -
A 25-Year-Old Man with Exudative Retinal Detachments and Infiltrates without Hematological or Neurological Findings Found to Have Relapsed Precursor T-Cell Acute Lymphoblastic Leukemia
(S. Karger AG, 2015)Background: Precursor T-cell acute lymphoblastic leukemia (pre-T-ALL) may cause ocular pathologies such as cotton-wool spots, retinal hemorrhage, and less commonly, retinal detachment or leukemic infiltration of the retina ... -
2K09 and Thereafter : The Coming Era of Integrative Bioinformatics, Systems Biology and Intelligent Computing for Functional Genomics and Personalized Medicine Research
(BioMed Central, 2010)Significant interest exists in establishing synergistic research in bioinformatics, systems biology and intelligent computing. Supported by the United States National Science Foundation (NSF), International Society of ... -
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water.
(2002)There is limited information on the prevalence of the potent mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in U.S. water supplies. We measured MX concentrations and mutagenic activity in tap water samples ... -
3-D Microwell Array System for Culturing Virus Infected Tumor Cells
(Nature Publishing Group, 2016)Cancer cells have been increasingly grown in pharmaceutical research to understand tumorigenesis and develop new therapeutic drugs. Currently, cells are typically grown using two-dimensional (2-D) cell culture approaches, ... -
3-dimensional digital reconstruction of the murine coronary system for the evaluation of chronic allograft vasculopathy
(BioMed Central, 2015)Background: Chronic allograft vasculopathy (CAV) is a major mechanism of graft failure of transplanted organs in humans. Morphometric analysis of coronary arteries enables the quantitation of CAV in mouse models of heart ... -
3.28 At-Home Functional Impairment in Youth With Attention-Deficit/Hyperactivity Disorder (ADHD): Factor Structure and Norm-Referenced Cut-Off Points for the Before School Functioning Questionnaire and Parent Rating of Evening and Morning Behavior Scale, Revised
(Elsevier BV, 2017-10)Objective. Children with attention deficit hyperactivity disorder (ADHD) frequently manifest behavioral difficulties in the morning prior to school and in the afternoons and evenings. We sought to establish norms for two ... -
3D Cell Nuclei Segmentation Based on Gradient Flow Tracking
(BioMed Central, 2007)Background: Reliable segmentation of cell nuclei from three dimensional (3D) microscopic images is an important task in many biological studies. We present a novel, fully automated method for the segmentation of cell nuclei ... -
3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
(BioMed Central, 2017)Many mutations in cancer are of unknown functional significance. Standard methods use statistically significant recurrence of mutations in tumor samples as an indicator of functional impact. We extend such analyses into ... -
3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”
(BioMed Central, 2016)Alzheimer’s disease (AD) transgenic mice have been used as a standard AD model for basic mechanistic studies and drug discovery. These mouse models showed symbolic AD pathologies including β-amyloid (Aβ) plaques, gliosis ... -
A 3D Human Neural Cell Culture System for Modeling Alzheimer's Disease
(Springer Science and Business Media LLC, 2015-06-11)Stem cell technologies have facilitated the development of human cellular disease models that can be used to study pathogenesis and test therapeutic candidates. These models hold promise for complex neurological diseases ...