Browsing Harvard Medical School by Title

Now showing items 1486-1505 of 18428

    • Automated Discovery of Functional Generality of Human Gene Expression Programs 

      Gerber, Georg Kurt; Dowell, Robin D; Jaakkola, Tommi S; Gifford, David Kenneth (Public Library of Science, 2007)
      An important research problem in computational biology is the identification of expression programs, sets of co-expressed genes orchestrating normal or pathological processes, and the characterization of the functional ...

    • Automated DNA Mutation Detection Using Universal Conditions Direct Sequencing: Application to Ten Muscular Dystrophy Genes 

      Bennett, Richard R; Schneider, Hal E; Estrella, Elicia; Burgess, Stephanie; Cheng, Andrew S; Barrett, Caitlin; Lip, Va; Lai, Poh San; Shen, Yiping; Wu, Bai-Lin; Darras, Basil T.; Beggs, Alan Hendrie; Kunkel, Louis Martens (BioMed Central, 2009)
      Background: One of the most common and efficient methods for detecting mutations in genes is PCR amplification followed by direct sequencing. Until recently, the process of designing PCR assays has been to focus on individual ...

    • Automated grading system for evaluation of ocular redness associated with dry eye 

      Rodriguez, John D; Johnston, Patrick R; Ousler, George W; Smith, Lisa M; Abelson, Mark B (Dove Medical Press, 2013)
      Background: We have observed that dry eye redness is characterized by a prominence of fine horizontal conjunctival vessels in the exposed ocular surface of the interpalpebral fissure, and have incorporated this feature ...

    • Automated Identification of Acute Hepatitis B Using Electronic Medical Record Data to Facilitate Public Health Surveillance 

      Haney, Gillian; Church, Daniel; Hou, Xuanlin; Ramsay, Mary; Klompas, Michael; Lazarus, Ross; Platt, Richard (Public Library of Science, 2008)
      Background: Automatic identification of notifiable diseases from electronic medical records can potentially improve the timeliness and completeness of public health surveillance. We describe the development and implementation ...

    • Automated Methods for Surveillance of Surgical Site Infections 

      Platt, Richard; Yokoe, Deborah Stephanie; Sands, Kenneth Eliot Frederick (Centers for Disease Control, 2001)
      Automated data, especially from pharmacy and administrative claims, are available for much of the U.S. population and might substantially improve both inpatient and postdischarge surveillance for surgical site infections ...

    • Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers 

      Riahi, Reza; Shaegh, Seyed Ali Mousavi; Ghaderi, Masoumeh; Zhang, Yu Shrike; Shin, Su Ryon; Aleman, Julio; Massa, Solange; Kim, Duckjin; Dokmeci, Mehmet Remzi; Khademhosseini, Ali (Nature Publishing Group, 2016)
      There is an increasing interest in developing microfluidic bioreactors and organs-on-a-chip platforms combined with sensing capabilities for continual monitoring of cell-secreted biomarkers. Conventional approaches such ...

    • Automated Modelling of Signal Transduction Networks 

      Steffen, Martin; Petti, Allegra; Aach, John Dennis; D'haeseleer, Patrik; Church, George McDonald (BioMed Central, 2002)
      Background: Intracellular signal transduction is achieved by networks of proteins and small molecules that transmit information from the cell surface to the nucleus, where they ultimately effect transcriptional changes. ...

    • Automated motion artifact removal for intravital microscopy, without a priori information 

      Lee, Sungon; Vinegoni, Claudio; Sebas, Matthew; Weissleder, Ralph (Nature Publishing Group, 2014)
      Intravital fluorescence microscopy, through extended penetration depth and imaging resolution, provides the ability to image at cellular and subcellular resolution in live animals, presenting an opportunity for new insights ...

    • Automated neuron tracking inside moving and deforming C. elegans using deep learning and targeted augmentation 

      Park, Core Francisco; Barzegar-Keshteli, Mahsa; Korchagina, Kseniia; Delrocq, Ariane; Susoy, Vladislav; Jones, Corrine; Samuel, Aravinthan DT; Rahi, Sahand J (Springer Science and Business Media LLC, 2023-12-05)
      Recent advances allow sustained rapid 3D functional imaging of large numbers of neurons inside behaving animals. To decode neural activity, individual neurons must be segmented and tracked. This can be challenging inside ...

    • Automated real time constant-specificity surveillance for disease outbreaks 

      Wieland, Shannon C; Brownstein, John Samuel; Berger, Bonnie; Mandl, Kenneth David (BioMed Central, 2007)
      Background: For real time surveillance, detection of abnormal disease patterns is based on a difference between patterns observed, and those predicted by models of historical data. The usefulness of outbreak detection ...

    • Automated Screening of Microtubule Growth Dynamics Identifies MARK2 as a Regulator of Leading Edge Microtubules Downstream of Rac1 in Migrating Cells 

      Nishimura, Yukako; Applegate, Kathryn; Davidson, Michael W.; Danuser, Gaudenz; Waterman, Clare M. (Public Library of Science, 2012)
      Polarized microtubule (MT) growth in the leading edge is critical to directed cell migration, and is mediated by Rac1 GTPase. To find downstream targets of Rac1 that affect MT assembly dynamics, we performed an RNAi screen ...

    • Automated Sulcal Depth Measurement on Cortical Surface Reflecting Geometrical Properties of Sulci 

      Yun, Hyuk Jin; Im, Kiho; Jin-Ju Yang; Yoon, Uicheul; Lee, Jong-Min (Public Library of Science, 2013)
      Sulcal depth that is one of the quantitative measures of cerebral cortex has been widely used as an important marker for brain morphological studies. Several studies have employed Euclidean (EUD) or geodesic (GED) algorithms ...

    • Automated Synthesis and Visualization of a Chemotherapy Treatment Regimen Network 

      Warner, Jeremy; Yang, Peter; Alterovitz, Gil (2013)
      Cytotoxic treatments for cancer remain highly toxic, expensive, and variably efficacious. Many chemotherapy regimens are never directly compared in randomized clinical trials (RCTs); as a result, the vast majority of ...

    • Automated System for Gathering and Reporting Clinical Outcomes to Providers 

      Gross, Benjamin (2015-09-29)
      BACKGROUND: Automated communication systems can help healthcare providers learn about their patients’ outcomes to detect patients who haven’t improved as expected. OBJECTIVE: To provide feedback to healthcare providers on ...

    • Automated Validation Of Genetic Variants From Large Databases: Ensuring That Variant References Refer To The Same Genomic Locations 

      Tong, Mark Y.; Cassa, Christopher Anthony; Kohane, Isaac Samuel (Oxford University Press, 2011)
      Accurate annotations of genomic variants are necessary to achieve full-genome clinical interpretations that are scientifically sound and medically relevant. Many disease associations, especially those reported before the ...

    • Automated Vocabulary Discovery for Geo-Parsing Online Epidemic Intelligence 

      Keller, Mikaela; Freifeld, Clark C; Brownstein, John Samuel (BioMed Central, 2009)
      Background Automated surveillance of the Internet provides a timely and sensitive method for alerting on global emerging infectious disease threats. HealthMap is part of a new generation of online systems designed to monitor ...

    • Automated white matter fiber tract identification in patients with brain tumors 

      O’Donnell, Lauren J.; Suter, Yannick; Rigolo, Laura; Kahali, Pegah; Zhang, Fan; Norton, Isaiah; Albi, Angela; Olubiyi, Olutayo; Meola, Antonio; Essayed, Walid I.; Unadkat, Prashin; Ciris, Pelin Aksit; Wells, William M.; Rathi, Yogesh; Westin, Carl-Fredrik; Golby, Alexandra J. (Elsevier, 2016)
      We propose a method for the automated identification of key white matter fiber tracts for neurosurgical planning, and we apply the method in a retrospective study of 18 consecutive neurosurgical patients with brain tumors. ...

    • Automatic clustering and population analysis of white matter tracts using maximum density paths 

      Prasad, Gautam; Joshi, Shantanu H.; Jahanshad, Neda; Villalon-Reina, Julio; Aganj, Iman; Lenglet, Christophe; Sapiro, Guillermo; McMahon, Katie L.; de Zubicaray, Greig I.; Martin, Nicholas G.; Wright, Margaret J.; Toga, Arthur W.; Thompson, Paul M. (Elsevier BV, 2014-08)
      We introduce a framework for population analysis of white matter tracts based on diffusion-weighted images of the brain. The framework enables extraction of fibers from high angular resolution diffusion images (HARDI); ...

    • Automatic detection of ventilatory modes during invasive mechanical ventilation 

      Murias, Gastón; Montanyà, Jaume; Chacón, Encarna; Estruga, Anna; Subirà, Carles; Fernández, Rafael; Sales, Bernat; de Haro, Candelaria; López-Aguilar, Josefina; Lucangelo, Umberto; Villar, Jesús; Kacmarek, Robert M.; Blanch, Lluís (BioMed Central, 2016)
      Background: Expert systems can help alleviate problems related to the shortage of human resources in critical care, offering expert advice in complex situations. Expert systems use contextual information to provide advice ...

    • Automatic Identification of Environment Haptic Properties 

      Dupont, Pierre E; Schulteis, Capt. Timothy M.; Millman, Paul A.; Howe, Robert D. (MIT Press - Journals, 1999)
      Many applications can be imagined for a system that processes sensory information collected during telemanipulation tasks in order to automatically identify properties of the remote environment. These applications include ...