Browsing Harvard Medical School by Title

Now showing items 1709-1728 of 18428

    • Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson’s Disease 

      Smirnova, Natalya A.; Kaidery, Navneet Ammal; Hushpulian, Dmitry M.; Rakhman, Ilay I.; Poloznikov, Andrey A.; Tishkov, Vladimir I.; Karuppagounder, Saravanan S.; Gaisina, Irina N.; Pekcec, Anton; Leyen, Klaus Van; Kazakov, Sergey V.; Yang, Lichuan; Thomas, Bobby; Ratan, Rajiv R.; Gazaryan, Irina G. (JKL International LLC, 2016)
      Flavonoids are known to trigger the intrinsic genetic adaptive programs to hypoxic or oxidative stress via estrogen receptor engagement or upstream kinase activation. To reveal specific structural requirements for direct ...

    • Bioavailable Vitamin D Is More Tightly Linked to Mineral Metabolism than Total Vitamin D in Incident Hemodialysis Patients 

      Bhan, Ishir; Powe, Camille Elise; Berg, Anders Hayden; Ankers, Elizabeth; Wenger, Julia; Karumanchi, Subbian Ananth; Thadhani, Ravi Ishwar (Nature Publishing Group, 2012)
      Prior studies showed conflicting results regarding the association between 25-hydroxyvitamin D (25(OH)D) levels and mineral metabolism in end-stage renal disease. In order to determine whether the bioavailable vitamin D ...

    • A BioBrick compatible strategy for genetic modification of plants 

      Boyle, Patrick M; Burrill, Devin Rene; Inniss, Mara Christine; Agapakis, Christina M; Deardon, Aaron; dewerd, Jonathan G; Gedeon, Michael A; Quinn, Jacqueline Y; Paull, Morgan L; Raman, Anugraha M; Theilmann, Mark R; Wang, Lu; Winn, Julia C; Medvedik, Oliver; Schellenberg, Kurt William; Haynes, Karmella; Viel, Alain; Brenner, Tamara Jane; Church, George McDonald; Shah, Jagesh V.; Silver, Pamela A. (BioMed Central, 2012)
      Background: Plant biotechnology can be leveraged to produce food, fuel, medicine, and materials. Standardized methods advocated by the synthetic biology community can accelerate the plant design cycle, ultimately making ...

    • BioC: a minimalist approach to interoperability for biomedical text processing 

      Comeau, Donald C.; Islamaj Doğan, Rezarta; Ciccarese, Paolo; Cohen, Kevin Bretonnel; Krallinger, Martin; Leitner, Florian; Lu, Zhiyong; Peng, Yifan; Rinaldi, Fabio; Torii, Manabu; Valencia, Alfonso; Verspoor, Karin; Wiegers, Thomas C.; Wu, Cathy H.; Wilbur, W. John (Oxford University Press, 2013)
      A vast amount of scientific information is encoded in natural language text, and the quantity of such text has become so great that it is no longer economically feasible to have a human as the first step in the search ...

    • Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins 

      McLaughlin-Drubin, Margaret E.; Munger, Karl (MDPI, 2013)
      The role of enzymes involved in polycomb repression of gene transcription has been studied extensively in human cancer. Polycomb repressive complexes mediate oncogene-induced senescence, a principal innate cell-intrinsic ...

    • Biochemical Characterization of Novel Retroviral Integrase Proteins 

      Ballandras-Colas, Allison; Naraharisetty, Hema; Li, Xiang; Serrao, Erik; Engelman, Alan (Public Library of Science, 2013)
      Integrase is an essential retroviral enzyme, catalyzing the stable integration of reverse transcribed DNA into cellular DNA. Several aspects of the integration mechanism, including the length of host DNA sequence duplication ...

    • Biochemical Phenotypes to Discriminate Microbial Subpopulations and Improve Outbreak Detection 

      Galar, Alicia; Kulldorff, Martin; Rudnick, Wallis; O'Brien, Thomas F.; Stelling, John (Public Library of Science, 2013)
      Background: Clinical microbiology laboratories worldwide constitute an invaluable resource for monitoring emerging threats and the spread of antimicrobial resistance. We studied the growing number of biochemical tests ...

    • Biochemical, Biophysical, and Mutational Analyses of Subunit Interactions of the Human Cytomegalovirus Nuclear Egress Complex 

      Sam, My; Evans, Brady; Coen, Donald; Hogle, James (American Society for Microbiology, 2009)
      Nuclear egress, the trafficking of herpesvirus nucleocapsids from the nucleus to the cytoplasm, involves two conserved viral proteins that form a complex at the nuclear envelope, referred to as the nuclear egress complex. ...

    • Biocompatibility and biofilm inhibition of N,N-hexyl,methyl-polyethylenimine bonded to Boston Keratoprosthesis materials 

      Behlau, Irmgard; Mukherjee, Koushik; Todani, Amit; Tisdale, Ann S.; Cade, Fabiano; Wang, Liqiang; Leonard, Elizabeth M.; Zakka, Fouad R.; Gilmore, Michael S.; Jakobiec, Frederick A.; Dohlman, Claes Henrik; Klibanov, Alexander M. (Elsevier BV, 2011)
      The biocompatibility and antibacterial properties of N,N-hexyl,methyl-polyethylenimine (HMPEI) covalently attached to the Boston Keratoprosthesis (B-KPro) materials was evaluated. By means of confocal and electron microscopies, ...

    • Biocompatible Pressure Sensing Skins for Minimally Invasive Surgical Instruments 

      Arabagi, Veaceslav; Felfoul, Ouajdi; Gosline, Andrew H.; Wood, Robert J.; Dupont, Pierre E (Institute of Electrical and Electronics Engineers (IEEE), 2016)
      Kinematic models of concentric tube robots have matured from considering only tube bending to considering tube twisting as well as external loading. While these models have been demonstrated to approximate actual behavior, ...

    • Biocomputing Enters its Adolescence 

      Sunyaev, Shamil R. (BioMed Central, 2005)

    • The Bioconductor channel in F1000Research 

      Huber, Wolfgang; Carey, Vincent; Davis, Sean; Hansen, Kasper Daniel; Morgan, Martin (F1000Research, 2015)
      Bioconductor ( bioconductor.org) is a rich source of software and know-how for the integrative analysis of genomic data. The Bioconductor channel in F1000Research provides a forum for task-oriented workflows that each cover ...

    • Biocontainment of Genetically Modified Organisms by Synthetic Protein Design 

      Mandell, Daniel; Lajoie, Marc J.; Mee, Michael T.; Takeuchi, Ryo; Kuznetsov, Gleb; Norville, Julie; Gregg, Christopher J.; Stoddard, Barry L.; Church, George (Nature Research, 2015-02-05)
      Genetically modified organisms (GMOs) are increasingly deployed at large scales and in open environments. Genetic biocontainment strategies are needed to prevent unintended proliferation of GMOs in natural ecosystems. ...

    • Biodistribution of Charged 17.1A Photoimmunoconjugates in a Murine Model of Hepatic Metastasis of Colorectal Cancer 

      Governatore, M Del; Rizvi, I; Hasan, T; Hamblin, Michael (Springer Nature, 2000-12)

    • Biodistribution of Charged F(ab')2 Photoimmunoconjugates in a Xenograft Model of Ovarian Cancer 

      Duska, LR; Bamberg, MP; Hasan, T; Hamblin, Michael (Springer Nature, 1997-03)
      The effect of charge modification of photoimmunoconjugates (PICs) on their biodistribution in a xenograft model of ovarian cancer was investigated. Chlorine(e6) c(e6) was attached site specifically to the F(ab')(2) fragment ...

    • Bioelectric Signaling Regulates Size in Zebrafish Fins 

      Perathoner, Simon; Daane, Jacob M.; Henrion, Ulrike; Seebohm, Guiscard; Higdon, Charles W.; Johnson, Stephen L.; Nüsslein-Volhard, Christiane; Harris, Matthew P. (Public Library of Science, 2014)
      The scaling relationship between the size of an appendage or organ and that of the body as a whole is tightly regulated during animal development. If a structure grows at a different rate than the rest of the body, this ...

    • Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells 

      St-Pierre, Julie; Lin, Jiandie; Krauss, Stefan; Tarr, Paul T.; Yang, Ruojing; Newgard, Christopher B.; Spiegelman, Bruce M. (American Society for Biochemistry and Molecular Biology, 2003)
      Peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha is a coactivator of nuclear receptors and other transcription factors that regulates several components of energy metabolism, particularly certain ...

    • Bioenergetic Measurements in Children with Bipolar Disorder: A Pilot \(^{31}\)P Magnetic Resonance Spectroscopy Study 

      Sikoglu, Elif M.; Jensen, John Eric; Vitaliano, Gordana Dragan; Liso Navarro, Ana A.; Renshaw, Perry Franklin; Frazier, Jean A.; Moore, Constance M. (Public Library of Science, 2013)
      Background: Research exploring Bipolar Disorder (BD) phenotypes and mitochondrial dysfunction, particularly in younger subjects, has been insufficient to date. Previous studies have found abnormal cerebral pH levels in ...

    • Bioengineered Self-assembled Skin as an Alternative to Skin Grafts 

      Climov, Mihail; Medeiros, Erika; Farkash, Evan A.; Qiao, Jizeng; Rousseau, Cecile F.; Dong, Shumin; Zawadzka, Agatha; Racki, Waldemar J.; Al-Musa, Ahmad; Sachs, David H.; Randolph, Mark A.; Huang, Christene A.; Bollenbach, Thomas J. (Wolters Kluwer Health, 2016)
      For patients with extensive burns or donor site scarring, the limited availability of autologous and the inevitable rejection of allogeneic skin drive the need for new alternatives. Existing engineered biologic and synthetic ...

    • Biofeedback Improves Postural Control Recovery From Multi-Axis Discrete Perturbations 

      Sienko, Kathleen H; Balkwill, M David; Wall, Conrad (BioMed Central, 2012)
      Background: Multi-axis vibrotactile feedback has been shown to significantly reduce the root-mean-square (RMS) sway, elliptical fits to sway trajectory area, and the time spent outside of the no feedback zone in individuals ...