Browsing Harvard Medical School by Title
Now showing items 1769-1788 of 18423
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The biomarkers of immune dysregulation and inflammation response in Parkinson disease
(BioMed Central, 2016)Parkinson’s disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histocompatibility ... -
Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons
(National Institute of Environmental Health Sciences, 2010)Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ... -
Biomarkers of Sarcopenia in Clinical Trials—Recommendations from the International Working Group on Sarcopenia
(Springer-Verlag, 2012)Sarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons. The study of this phenomenon and the development of preventive/therapeutic ... -
Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases
(BioMed Central, 2016)Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic ... -
Biomarkers: A Challenging Conundrum in Cardiovascular Disease
(Ovid Technologies (Wolters Kluwer Health), 2015)The use of biomarkers has proven utility in cardiovascular medicine and holds great promise for future advances, but their application requires considerable rigor in thinking and methodology. Numerous confounding factors ... -
Biomarkers: the next therapeutic hurdle in metastatic renal cell carcinoma
(Nature Publishing Group, 2012)Despite recent advances, metastatic renal cell carcinoma remains largely an incurable disease. Vascular endothelial growth factor and mammalian target of rapamycin inhibitors have provided improvements in clinical outcomes. ... -
Biomaterials and emerging anticancer therapeutics: engineering the microenvironment
(Nature Publishing Group, 2015)The microenvironment is increasingly recognized to have key roles in cancer, and biomaterials provide a means to engineer microenvironments both in vitro and in vivo to study and manipulate cancer. In vitro cancer models ... -
Biomechanical Analyses of Novel Techniques for Knee Meniscus Repair and Proximal Subpectoral Biceps Tenodesis
(2015-06-17)Background: Many all-inside suture-based devices are currently available, including the Meniscal Cinch, FasT-Fix, Ultra FasT-Fix, RapidLoc, MaxFire, and CrossFix System. These different devices have been compared in various ... -
Biomechanical Considerations in the Pathogenesis of Osteoarthritis of the Knee
(Springer-Verlag, 2011)Osteoarthritis is the most common joint disease and a major cause of disability. The knee is the large joint most affected. While chronological age is the single most important risk factor of osteoarthritis, the pathogenesis ... -
Biomechanical forces promote blood development through prostaglandin E2 and the cAMP–PKA signaling axis
(The Rockefeller University Press, 2015)Blood flow promotes emergence of definitive hematopoietic stem cells (HSCs) in the developing embryo, yet the signals generated by hemodynamic forces that influence hematopoietic potential remain poorly defined. Here we ... -
Biomedical Applications of Tetrazine Cycloadditions
(American Chemical Society, 2011)Disease mechanisms are increasingly being resolved at the molecular level. Biomedical success at this scale creates synthetic opportunities for combining specifically designed orthogonal reactions In applications such as ... -
Biomedical Markers and Psychiatric Morbidity of Neurasthenia Spectrum Disorders in Four Outpatient Clinics in India
(Medknow Publications, 2008)Context:Disorders of unexplained fatigue are researched globally and debated prominently concerning their biomedical and psychiatric comorbidity. Such studies are needed in India. Aims: To identify biomedical markers ... -
BioNumbers—The Database of Key Numbers in Molecular and Cell Biology
(Oxford University Press, 2009)BioNumbers (http://www.bionumbers.hms.harvard.edu) is a database of key numbers in molecular and cell biology—the quantitative properties of biological systems of interest to computational, systems and molecular cell ... -
Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection
(Nature Research, 2010)Nanoparticles have emerged as key materials for biomedical applications because of their unique and tunable physical properties, multivalent targeting capability, and high cargo capacity(1,2). Motivated by these properties ... -
Bioorthogonal Click Chemistry-Based Synthetic Cell Glue
(Wiley, 2015)Artificial methods of cell adhesion can be effective in building functional cell complexes in vitro, but methods for in vivo use are currently lacking. Here, a chemical cell glue based on bioorthogonal click chemistry with ... -
Bioorthogonal Fluorophore Linked DFO–Technology Enabling Facile Chelator Quantification and Multimodal Imaging of Antibodies
(American Chemical Society, 2016)Herein we describe the development and application of a bioorthogonal fluorogenic chelate linker that can be used for facile creation of labeled imaging agents. The chelate linker is based on the trans-cyclooctene(TCO)-t ... -
Bioorthogonal Imaging of Aurora Kinase a in Live Cells
(Wiley, 2012)